Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Center for Evidence Based Chinese Medicine, Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100010, China.
BMC Complement Med Ther. 2021 Sep 13;21(1):228. doi: 10.1186/s12906-021-03387-y.
Traditional Chinese Medicine (TCM) has been a proposed treatment option for ulcerative colitis (UC), however it has been difficult to understand the breadth and depth of evidence as various Chinese medicine therapies may produce effects differently. The aim of this evidence mapping is to visually understand the available evidence in the use of TCM in the treatment of UC, and to identify gaps in evidence to inform priorities of future research.
A systematic electronic literature search of six databases were performed to identify systematic reviews (SRs) on different Chinese medicine therapies in the treatment in UC. Methodological quality of the included SRs was assessed using AMSTAR 2.
The mapping was based on 73 SRs, which included nine interventions that met eligibility criteria. The quality of the included SRs was very low. The diseases stages of patients with UC varied greatly, from active to remission, to non-acute outbreak, to not reported. The results mostly favored the method of intervention. Oral administration combined with enema was the most widely used route of administration in secondary research.
Based on the current evidence, the treatment of UC with TCM can only be recommended cautiously. A majority of included SRs did not report the location of the disease, the disease classification, and the route of administration of the intervention. Further research is needed on the effectiveness of Chinese medicine alone in the treatment of UC. The effectiveness of combined Chinese and conventional medicine combined with different routes of administration cannot be confirmed. Attention should be paid to the methodological quality of the systematic review. Unifies the outcome indicators used in the evaluation of effectiveness.
中药（TCM）一直被提议作为溃疡性结肠炎（UC）的治疗选择，然而，由于各种中药疗法可能产生不同的效果，因此很难理解证据的广度和深度。本证据图谱旨在直观了解中药治疗 UC 的现有证据，并确定证据中的空白，为未来研究确定优先事项。
对六个数据库进行了系统的电子文献检索，以确定不同中药疗法治疗 UC 的系统评价（SR）。使用 AMSTAR 2 评估纳入的 SR 的方法学质量。
该图谱基于 73 项 SR，其中包括 9 项符合入选标准的干预措施。纳入的 SR 质量非常低。UC 患者的疾病阶段差异很大，从活动期到缓解期，再到非急性发作期，再到未报告期。结果大多有利于干预方法。口服给药联合灌肠是二次研究中最广泛使用的给药途径。
基于目前的证据，只能谨慎推荐中药治疗 UC。大多数纳入的 SR 未报告疾病部位、疾病分类和干预措施的给药途径。需要进一步研究中药单独治疗 UC 的有效性。中药联合常规药物联合不同给药途径的有效性不能确定。应注意系统评价的方法学质量。统一评估有效性的结果指标。
