围生期感染 SARS-CoV-2 的母亲所分娩新生儿的管理和近期结局。
Management and short-term outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection.
机构信息
Division of Neonatology, Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA.
Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA.
出版信息
BMC Pediatr. 2021 Sep 13;21(1):400. doi: 10.1186/s12887-021-02872-0.
OBJECTIVE
We report here on the management and outcomes of neonates born to mothers with active perinatal SARS-CoV-2 infection.
STUDY DESIGN
In this prospective study, eligible neonates were enrolled in a database to track in-hospital outcomes and followed up outpatient periodically till 2 months of age to assess for late onset symptoms of infection.
RESULTS
From April 2020 to February 2021, 67 mothers with perinatal SARS-CoV-2 infection and 70 at-risk neonates were included. Two neonates (3%) tested positive for SARS-CoV-2 within 48 h of life but remained asymptomatic during hospitalization and at all follow-up periods. Three infants were reported to have a febrile illness in 2 months follow up period, none of which was attributable to SARS-CoV-2.
CONCLUSION
Our data supports the emerging evidence which describes a probable low risk of vertical transmission of SARS-CoV-2. We also demonstrate a low risk of post-natal transmission or late-onset symptomatic infection with SARS-CoV-2.
目的
我们在此报告患有围产期 SARS-CoV-2 感染的母亲所生新生儿的管理和结局。
研究设计
在这项前瞻性研究中，符合条件的新生儿被纳入数据库以跟踪住院期间的结局，并定期进行门诊随访，直至 2 个月龄，以评估迟发性感染症状。
结果
2020 年 4 月至 2021 年 2 月，纳入了 67 例围产期 SARS-CoV-2 感染的母亲和 70 例有风险的新生儿。2 名新生儿（3%）在出生后 48 小时内 SARS-CoV-2 检测呈阳性，但在住院期间和所有随访期间均无症状。3 名婴儿在 2 个月随访期间报告有发热疾病，但均与 SARS-CoV-2 无关。
结论
我们的数据支持新兴证据，即 SARS-CoV-2 垂直传播的风险可能较低。我们还表明，SARS-CoV-2 的产后传播或迟发性有症状感染的风险较低。
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