Department of Chemistry, New York University, New York, NY 10003, USA.
Chem Commun (Camb). 2021 Sep 14;57(73):9192-9195. doi: 10.1039/d1cc02704b.
A metal-free and achiral tri-pyridylamide foldamer, DM 11, containing a critical naphthalimide side chain self-assembles in a left-handed helical manner in the presence of chiral adenosine phosphates, under physiological conditions. Surprisingly, a very high degree of helicity in the foldamer assemblies was observed with ADP compared to other nucleoside phosphates, including ATP.
一种不含金属和手性的三吡啶酰胺折叠体 DM11，在生理条件下，在含有手性腺苷磷酸盐的情况下，通过关键的萘酰亚胺侧链自组装成左手螺旋构象。令人惊讶的是，与其他核苷磷酸盐相比，ADP 使折叠体组装具有非常高的螺旋度，包括 ATP。
