Department of Biological Science, University of Ulsan, Ulsan, 44610, South Korea; Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012, South Korea.
Department of Biological Science, University of Ulsan, Ulsan, 44610, South Korea.
Biochem Biophys Res Commun. 2021 Nov 12;578:1-6. doi: 10.1016/j.bbrc.2021.08.081. Epub 2021 Aug 29.
Developmentally regulated GTP-binding protein 2 (DRG2) participates in the regulation of proliferation and differentiation of multiple cells. However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2. Consistent with these results, DRG2 Tg mice showed increased expression of genes involved in adipogenesis and lipid metabolism in the white adipose tissue. DRG2 was also identified to control adipogenesis by cooperating with peroxisome proliferator activated receptor-γ (PPAR-γ) in cultured adipocytes. Overall, the findings of the current study suggest that DRG2 plays an active role in regulating adipocyte differentiation, and thus participates in the development of obesity during exposure to a fat-rich diet.
发育调节鸟苷三磷酸结合蛋白 2（DRG2）参与多种细胞增殖和分化的调节。然而，DRG2 是否调节脂肪细胞分化和相关的代谢控制尚不清楚。本研究揭示了过表达 DRG2 的 DRG2 转基因（Tg）小鼠体重和肥胖增加。与这些结果一致，DRG2 Tg 小鼠的白色脂肪组织中参与脂肪生成和脂质代谢的基因表达增加。在培养的脂肪细胞中，DRG2 还通过与过氧化物酶体增殖物激活受体-γ（PPAR-γ）合作来控制脂肪生成。总的来说，本研究的结果表明，DRG2 在调节脂肪细胞分化中起积极作用，因此在高脂肪饮食暴露期间参与肥胖的发展。
