Nutritional Department, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Gaoqiao Town, Pudong New Area, Shanghai, China.
Physiol Res. 2020 Nov 16;69(5):759-773. doi: 10.33549/physiolres.934411. Epub 2020 Sep 9.
In as early as 1997, the World Health Organization officially recognized obesity as a chronic disease. The current epidemic of obesity and overweightness has aroused great interest in the study of adipose tissue formation. The transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) binds to the target gene promoter regulatory sequences, acting as a key factor in regulating the differentiation of preadipocytes in the adipose tissue, and plays an important role in regulating the adipocyte metabolism. A further understanding of the structure and expression characteristics of PPARgamma, in addition to its mechanisms of action in adipocyte differentiation, may be applied to control obesity and prevent obesity-related diseases. In this article, recent studies investigating the effect of regulating PPARgamma on adipocyte differentiation are reviewed. In particular, the structural characteristics, expression patterns, and molecular mechanisms of PPARgamma function in adipocyte differentiation are considered.
早在 1997 年，世界卫生组织就正式将肥胖认定为一种慢性疾病。目前肥胖和超重的流行引起了人们对脂肪组织形成研究的极大兴趣。转录因子过氧化物酶体增殖物激活受体γ（PPARγ）与靶基因启动子调控序列结合，作为调节脂肪组织前体细胞分化的关键因素，在调节脂肪细胞代谢中发挥重要作用。进一步了解 PPARγ 的结构和表达特征，除了其在脂肪细胞分化中的作用机制外，可能有助于控制肥胖和预防肥胖相关疾病。本文综述了近年来关于调节 PPARγ 对脂肪细胞分化影响的研究。特别考虑了 PPARγ 在脂肪细胞分化中的结构特征、表达模式和分子机制。
