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Ibrutinib induces durable remissions in treatment-naïve patients with CLL and 17p deletion and/or TP53 mutations.

作者信息

Sivina Mariela, Kim Ekaterina, Wierda William G, Ferrajoli Alessandra, Jain Nitin, Thompson Philip, Kantarjian Hagop, Keating Michael, Burger Jan A

机构信息

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

出版信息

Blood. 2021 Dec 16;138(24):2589-2592. doi: 10.1182/blood.2021012315.

DOI:10.1182/blood.2021012315
PMID:34521099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8832441/
Abstract
摘要

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J Clin Oncol. 2020 Dec 1;38(34):4042-4054. doi: 10.1200/JCO.20.00948. Epub 2020 Sep 28.
2
Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab for previously untreated chronic lymphocytic leukaemia (CLL14): follow-up results from a multicentre, open-label, randomised, phase 3 trial.维奈托克联合奥滨尤妥珠单抗与苯丁酸氮芥联合奥滨尤妥珠单抗治疗初治慢性淋巴细胞白血病（CLL14）：一项多中心、开放标签、随机、3 期临床试验的随访结果。
Lancet Oncol. 2020 Sep;21(9):1188-1200. doi: 10.1016/S1470-2045(20)30443-5.
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Ibrutinib for Chronic Lymphocytic Leukemia with Alterations.伊布替尼用于治疗伴有改变的慢性淋巴细胞白血病。
N Engl J Med. 2020 Jul 30;383(5):498-500. doi: 10.1056/NEJMc2005943.
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Treatment of Chronic Lymphocytic Leukemia.慢性淋巴细胞白血病的治疗
N Engl J Med. 2020 Jul 30;383(5):460-473. doi: 10.1056/NEJMra1908213.
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Clin Cancer Res. 2020 Aug 1;26(15):3918-3927. doi: 10.1158/1078-0432.CCR-19-2856. Epub 2020 Mar 24.
6
Long-term efficacy and safety of first-line ibrutinib treatment for patients with CLL/SLL: 5 years of follow-up from the phase 3 RESONATE-2 study.RESONATE-2 研究 5 年随访：伊布替尼一线治疗 CLL/SLL 患者的长期疗效和安全性。
Leukemia. 2020 Mar;34(3):787-798. doi: 10.1038/s41375-019-0602-x. Epub 2019 Oct 18.
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Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia.伊布替尼联合利妥昔单抗与化疗免疫治疗慢性淋巴细胞白血病的比较
N Engl J Med. 2019 Aug 1;381(5):432-443. doi: 10.1056/NEJMoa1817073.
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Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL.伊布替尼方案与化疗免疫治疗在未经治疗的老年 CLL 患者中的比较。
N Engl J Med. 2018 Dec 27;379(26):2517-2528. doi: 10.1056/NEJMoa1812836. Epub 2018 Dec 1.
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Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial.初治 CLL 患者采用 FCR 化免治疗后的长期缓解：CLL8 试验的更新结果。
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