Neurology Department, Beni-Suef University, Beni-Suef, Egypt.
Department of Anaesthesia and Pain Management, Beni-Suef University, Beni-Suef, Egypt.
Brain Behav. 2021 Oct;11(10):e2349. doi: 10.1002/brb3.2349. Epub 2021 Sep 14.
There are controversies about the role of zinc in the development of both types 1 and 2 diabetes. The aim of this study was to assess serum zinc level in diabetic patients with and without peripheral neuropathy in comparison to healthy controls and to explore the possible relationship between serum zinc level and severity of peripheral neuropathy.
This case control study was conducted on 120 subjects: 40 patients fulfilled the criteria for diagnosis of probable diabetic polyneuropathy (DPN), 40 diabetic patients without polyneuropathy (N-DPN) and 40 healthy controls. DPN patients were submitted to clinical assessment of diabetic neuropathy using neuropathy symptom and change (NSC) scale, Michigan Neuropathy Screening Instrument Physical Assessment (MNSI) scale and electrophysiological assessment using nerve conduction study. Zinc serum level was measured in all subjects included in this study using direct colorimetric test method.
Diabetic patients with and without neuropathy were found to have significantly lower mean values of serum zinc than healthy controls (p = .025, .03 respectively). There is a statistically significant negative correlation between zinc serum level and hemoglobin A1C (HA1C) (p ˂ .001), NSC score (p = .001) and MNSI score (p = .003) in DPN group. There were also statistically significant correlations between zinc serum level and nerve conduction study values.
Zinc deficiency significantly correlates with the severity of DPN and glycemic control.
锌在 1 型和 2 型糖尿病的发展中的作用存在争议。本研究旨在评估糖尿病伴或不伴周围神经病变患者的血清锌水平，并与健康对照组进行比较，同时探讨血清锌水平与周围神经病变严重程度的可能关系。
本病例对照研究共纳入 120 例受试者：40 例患者符合糖尿病多发性神经病变（DPN）的诊断标准，40 例糖尿病无多发性神经病变（N-DPN）患者，40 例健康对照者。DPN 患者接受神经病症状和变化（NSC）量表、密歇根神经病变筛查工具物理评估（MNSI）量表和神经传导研究的电生理学评估，以对糖尿病周围神经病变进行临床评估。采用直接比色法测定所有研究对象的血清锌水平。
有周围神经病变和无周围神经病变的糖尿病患者的血清锌平均值均显著低于健康对照组（p=.025，p=.03）。DPN 组血清锌水平与血红蛋白 A1C（HA1C）（p ˂.001）、NSC 评分（p=.001）和 MNSI 评分（p=.003）呈显著负相关。血清锌水平与神经传导研究值之间也存在显著相关性。
锌缺乏与 DPN 的严重程度和血糖控制显著相关。
