Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Diabetol Metab Syndr. 2012 Apr 19;4(1):13. doi: 10.1186/1758-5996-4-13.
The number of people with diabetes and pre-diabetes are exponentially increasing. Studies on humans have shown the beneficial effects of Zinc supplementation in patients with diabetes. The present study aims to systematically evaluate the literature and meta-analyze the effects of Zinc supplementation on diabetes. A systematic review of published studies reporting the effects of Zinc supplementations on diabetes mellitus was undertaken. The literature search was conducted in the following databases; PubMed, Web of Science and SciVerse Scopus. A meta-analysis of studies examining the effects of Zinc supplementation on clinical and biochemical parameters in patients with diabetes was performed. The total number of articles included in the present review is 25, which included 3 studies on type-1 diabetes and 22 studies on type-2 diabetes. There were 12 studies comparing the effects of Zinc supplementation on fasting blood glucose in patients with type-2 diabetes. The pooled mean difference in fasting blood glucose between Zinc supplemented and placebo groups was 18.13mg/dl (95%CI:33.85,2.41; p<0.05). 2-h post-prandial blood sugar also shows a similar distinct reduction in (34.87mg/dl [95%CI:75.44; 5.69]) the Zinc treated group. The reduction in HbA1c was 0.54% (95%CI:0.86;0.21) in the Zinc treated group. There were 8 studies comparing the effects of Zinc supplementation on lipid parameters in patients with type-2 diabetes. The pooled mean difference for total cholesterol between Zinc supplemented and placebo groups was 32.37mg/dl (95%CI:57.39,7.35; p<0.05). Low-density lipoprotein cholesterol also showed a similar distinct reduction in the Zinc treated group, the pooled mean difference from random effects analysis was 11.19mg/dl (95%CI:21.14,1.25; p<0.05). Studies have also shown a significant reduction in systolic and diastolic blood pressures after Zinc supplementation. This first comprehensive systematic review and meta-analysis on the effects of Zinc supplementation in patients with diabetes demonstrates that Zinc supplementation has beneficial effects on glycaemic control and promotes healthy lipid parameters. Further studies are required to identify the exact biological mechanisms responsible for these results.
患糖尿病和糖尿病前期的人数呈指数级增长。人类研究表明，锌补充剂对糖尿病患者有益。本研究旨在系统评估文献并对锌补充剂治疗糖尿病的效果进行荟萃分析。对报道锌补充剂对糖尿病影响的已发表研究进行了系统综述。文献检索在以下数据库进行：PubMed、Web of Science 和 SciVerse Scopus。对检查锌补充剂对糖尿病患者临床和生化参数影响的研究进行了荟萃分析。本综述共纳入 25 项研究，其中 3 项为 1 型糖尿病，22 项为 2 型糖尿病。有 12 项研究比较了锌补充剂对 2 型糖尿病患者空腹血糖的影响。锌补充组与安慰剂组之间空腹血糖的平均差值为 18.13mg/dl（95%CI：33.85，2.41；p<0.05）。2 小时餐后血糖在锌治疗组也有类似明显降低（34.87mg/dl [95%CI：75.44；5.69]）。锌治疗组 HbA1c 降低 0.54%（95%CI：0.86；0.21）。有 8 项研究比较了锌补充剂对 2 型糖尿病患者血脂参数的影响。锌补充组与安慰剂组之间总胆固醇的平均差值为 32.37mg/dl（95%CI：57.39，7.35；p<0.05）。低密度脂蛋白胆固醇在锌治疗组也有类似明显降低，随机效应分析的平均差值为 11.19mg/dl（95%CI：21.14，1.25；p<0.05）。研究还表明，锌补充后收缩压和舒张压均显著降低。这是首次对糖尿病患者锌补充效果的全面系统综述和荟萃分析，表明锌补充对血糖控制有益，并促进健康的血脂参数。需要进一步的研究来确定这些结果的确切生物学机制。
