Pan Yongli, Jiao Qingzheng, Wei Wei, Zheng Tianyang, Yang Xinyu, Xin Wenqiang
Department of Neurology, Weifang Medical University, Weifang, Shandong, People's Republic of China.
Second Department of Internal Medicine, Gucheng County Hospital, Gucheng, Hebei, People's Republic of China.
J Inflamm Res. 2021 Sep 7;14:4467-4483. doi: 10.2147/JIR.S327291. eCollection 2021.
As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient's prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF-κB and ERK.
作为一种关键的广泛存在的基因，长链非编码RNA（lncRNAs）在脑功能以及众多神经疾病尤其是缺血性卒中中大量存在且发挥着关键作用。缺血性卒中的潜在机制包括血管生成、自噬、凋亡、细胞死亡和神经炎症。炎症在缺血性卒中的病理过程中起着至关重要的作用，全身炎症会影响患者的预后。尽管大量研究表明各种lncRNAs与缺血性卒中中调节神经炎症和小胶质细胞激活密切相关，但lncRNAs与神经炎症之间具体的相互作用关系和机制尚未明确阐述。本综述旨在总结lncRNAs通过调节炎症和小胶质细胞激活对缺血的治疗作用及作用机制。此外，我们强调lncRNAs有潜力通过抑制和激活各种信号通路（如微小RNA、核因子κB和细胞外信号调节激酶）来调节炎症。
