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本文引用的文献

1
Follicular fat-soluble vitamins as markers of oocyte competency.卵泡脂溶性维生素作为卵母细胞能力的标志物。
Syst Biol Reprod Med. 2020 Apr;66(2):112-121. doi: 10.1080/19396368.2020.1718244. Epub 2020 Feb 14.
2
Effect of vitamin D status on normal fertilization rate following in vitro fertilization.维生素 D 状态对体外受精后正常受精率的影响。
Reprod Biol Endocrinol. 2019 Jul 18;17(1):59. doi: 10.1186/s12958-019-0500-0.
3
Comparison between cycles of the same patients when using recombinant luteinizing hormone + recombinant follicle stimulating hormone (rFSH), human menopausal gonadotropin + rFSH and rFSH only.使用重组促黄体生成素 + 重组促卵泡生成素（rFSH）、人绝经期促性腺激素 + rFSH 以及仅使用 rFSH 时同一患者各周期之间的比较。
Arch Med Sci. 2019 May;15(3):673-679. doi: 10.5114/aoms.2017.72408. Epub 2018 Jan 8.
4
Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation.关于促性腺激素对控制性卵巢刺激期间血清和卵泡液中游离脂肪酸和磷脂水平影响的假设。
Med Hypotheses. 2019 Feb;123:30-34. doi: 10.1016/j.mehy.2018.11.021. Epub 2018 Dec 18.
5
Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance.维生素 D 可改善多囊卵巢综合征伴胰岛素抵抗的不孕女性的体外受精结局。
Minerva Med. 2019 Jun;110(3):199-208. doi: 10.23736/S0026-4806.18.05946-3. Epub 2019 Jan 4.
6
Unexplained infertility: Is it over-diagnosed and over-treated?不明原因不孕：是否过度诊断和过度治疗？
Best Pract Res Clin Obstet Gynaecol. 2018 Nov;53:20-29. doi: 10.1016/j.bpobgyn.2018.09.006. Epub 2018 Oct 6.
7
Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study.多囊卵巢综合征（PCOS）患者的维生素 D 与代谢紊乱：一项横断面研究。
PLoS One. 2018 Dec 4;13(12):e0204748. doi: 10.1371/journal.pone.0204748. eCollection 2018.
8
Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility.维生素 D 缺乏与多囊卵巢综合征患者卵巢刺激结局不良相关，但与不明原因不孕无关。
J Clin Endocrinol Metab. 2019 Feb 1;104(2):369-378. doi: 10.1210/jc.2018-00750.
9
Vitamin D as a follicular marker of human oocyte quality and a serum marker of in vitro fertilization outcome.维生素 D 作为人卵母细胞质量的卵泡标志物和体外受精结局的血清标志物。
J Assist Reprod Genet. 2018 Jul;35(7):1265-1276. doi: 10.1007/s10815-018-1179-4. Epub 2018 May 17.
10
A preliminary evaluation of influence of body mass index on in vitro fertilization outcome in non-obese endometriosis patients.体重指数对非肥胖型子宫内膜异位症患者体外受精结局影响的初步评估
BMC Womens Health. 2017 Nov 16;17(1):112. doi: 10.1186/s12905-017-0457-0.

不明原因不孕症女性的卵泡及血清维生素D水平及其与受精结局的关系：一项观察性初步研究。

Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with fertilization outcome: an observational pilot study.

作者信息

Jeremic Ana, Mikovic Zeljko, Soldatovic Ivan, Sudar-Milovanovic Emina, Isenovic Esma R, Perovic Milan

机构信息

Clinic for Gynaecology and Obstetrics, "Narodni front", Belgrade, Serbia.

Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

出版信息

Arch Med Sci. 2021 Aug 17;17(5):1418-1422. doi: 10.5114/aoms/141185. eCollection 2021.

DOI:10.5114/aoms/141185
PMID:34522272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8425239/
Abstract

INTRODUCTION

Follicular and serum vitamin D are considered potential markers of the oocyte and embryos' quality and predictors of fertilization (IVF) outcomes.

METHODS

This retrospective cross-sectional study correlated vitamin D in sera and follicular fluid of women with unexplained infertility mutually and with IVF outcomes. ELISA was used for measuring vitamin D.

RESULTS

The results show positive correlation only between follicular and serum levels of vitamin D (Rho = 0.615, = 0.025), and between follicular levels of vitamin D and the percentage of embryo fragmentation (Rho = 0.544; = 0.036).

CONCLUSIONS

The results suggest that serum and follicular fluid vitamin D measurements could be complementary tools to the routine assessment of embryos.

摘要

引言

卵泡液和血清中的维生素D被认为是卵母细胞和胚胎质量的潜在标志物以及体外受精（IVF）结果的预测指标。

方法

这项回顾性横断面研究将不明原因不孕症女性的血清和卵泡液中的维生素D相互关联，并与IVF结果相关联。采用酶联免疫吸附测定法（ELISA）测量维生素D。

结果

结果显示仅卵泡液和血清中的维生素D水平之间存在正相关（Rho = 0.615，P = 0.025），以及卵泡液中的维生素D水平与胚胎碎片百分比之间存在正相关（Rho = 0.544；P = 0.036）。

结论

结果表明血清和卵泡液维生素D测量可能是胚胎常规评估的补充工具。