不明原因不孕症女性的卵泡及血清维生素D水平及其与受精结局的关系：一项观察性初步研究。
Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with fertilization outcome: an observational pilot study.
作者信息
Jeremic Ana, Mikovic Zeljko, Soldatovic Ivan, Sudar-Milovanovic Emina, Isenovic Esma R, Perovic Milan
机构信息
Clinic for Gynaecology and Obstetrics, "Narodni front", Belgrade, Serbia.
Institute of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
出版信息
Arch Med Sci. 2021 Aug 17;17(5):1418-1422. doi: 10.5114/aoms/141185. eCollection 2021.
Abstract
INTRODUCTION
Follicular and serum vitamin D are considered potential markers of the oocyte and embryos' quality and predictors of fertilization (IVF) outcomes.
METHODS
This retrospective cross-sectional study correlated vitamin D in sera and follicular fluid of women with unexplained infertility mutually and with IVF outcomes. ELISA was used for measuring vitamin D.
RESULTS
The results show positive correlation only between follicular and serum levels of vitamin D (Rho = 0.615, = 0.025), and between follicular levels of vitamin D and the percentage of embryo fragmentation (Rho = 0.544; = 0.036).
CONCLUSIONS
The results suggest that serum and follicular fluid vitamin D measurements could be complementary tools to the routine assessment of embryos.
摘要
引言
卵泡液和血清中的维生素D被认为是卵母细胞和胚胎质量的潜在标志物以及体外受精（IVF）结果的预测指标。
方法
这项回顾性横断面研究将不明原因不孕症女性的血清和卵泡液中的维生素D相互关联，并与IVF结果相关联。采用酶联免疫吸附测定法（ELISA）测量维生素D。
结果
结果显示仅卵泡液和血清中的维生素D水平之间存在正相关（Rho = 0.615，P = 0.025），以及卵泡液中的维生素D水平与胚胎碎片百分比之间存在正相关（Rho = 0.544；P = 0.036）。
结论
结果表明血清和卵泡液维生素D测量可能是胚胎常规评估的补充工具。
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