用于靶向光热肿瘤治疗的具有双受体靶向功能的基于石墨烯纳米带的超分子聚集体
Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy.
作者信息
Dou Wei-Tao, Xu Fugui, Xu Chen-Xi, Gao Jie, Ru Hong-Bo, Luan Xiangfeng, Zhang Jiacheng, Zhu Ling, Sedgwick Adam C, Chen Guo-Rong, Zang Yi, James Tony D, Tian He, Li Jia, Mai Yiyong, He Xiao-Peng
机构信息
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology 130 Meilong RD Shanghai 200237 P. R. China
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University 800 Dongchuan RD Shanghai 200240 P. R. China
出版信息
Chem Sci. 2021 Jul 15;12(33):11089-11097. doi: 10.1039/d1sc02154k. eCollection 2021 Aug 25.
Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αβ integrin receptors) targeting function, denoted as , for targeted photothermal treatment (PTT) of TNBC. The ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs () with a pyrene-tagged αβ integrin ligand (). Enhanced PTT efficacies were achieved both and compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with and then each mice group was subjected to PTT. Remarkably, induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy.
三阴性乳腺癌（TNBC）是乳腺癌中最具恶性的亚型之一。在此，我们报道了构建具有双受体（甘露糖和αβ整合素受体）靶向功能的基于石墨烯纳米带（GNR）的超分子聚集体，记为 ，用于TNBC的靶向光热治疗（PTT）。这些聚集体是通过甘露糖接枝的GNR（ ）与芘标记的αβ整合素配体（ ）基于溶液的自组装构建而成。与非靶向等效物相比， 和 均实现了增强的PTT疗效。给荷瘤活体小鼠（尾静脉）注射 ，然后对每组小鼠进行PTT。值得注意的是， 诱导实体瘤完全消融，并且在15天的时间内未观察到肿瘤复发。这项研究展示了一个用于开发用于靶向肿瘤治疗的光热纳米材料的新的有前景的平台。
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