利用石墨烯纳米带与壳聚糖包覆银纳米粒子的纳米线纳米复合材料实现近红外光触发的细菌根除。
Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles.
作者信息
Zhou Ming, Gan Hui-Qi, Chen Guo-Rong, James Tony D, Zhang Bin, Hu Qiang, Xu Fugui, Hu Xi-Le, He Xiao-Peng, Mai Yiyong
机构信息
Department of General Surgery, Shanghai Xuhui District Dahua Hospital, Shanghai, China.
Feringa Nobel Prize Scientist Joint Research Center, Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
出版信息
Front Chem. 2021 Oct 27;9:767847. doi: 10.3389/fchem.2021.767847. eCollection 2021.
Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with , a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.
细菌感染是对人类健康的重大威胁。然而，由于耐药性和副作用的出现，目前使用的许多抗菌剂受到严重限制。在此，我们开发了一种由壳聚糖（ChS）包覆的银纳米颗粒（AgNPs）和基于石墨烯纳米带（GNR）的纳米线组成的非抗生素纳米复合材料，用于光触发消除细菌。AgNP/ChS的存在显著增强了GNR纳米线与一种临床常见的革兰氏阴性菌的相互作用。这使得GNR在近红外光照射下能够高效地光热消除细菌。该纳米复合材料被证明可用于光触发消除细菌生物膜，并抑制用于腹壁疝手术的医用贴片上的细菌生长。
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