Khalid Kaynat, Khan Anas, Lomiguen Christine M, Chin Justin
Department of Primary Care, Lake Erie College of Osteopathic Medicine, Erie, USA.
Department of Medical Education, Lake Erie College of Osteopathic Medicine, Erie, USA.
Cureus. 2021 Aug 10;13(8):e17059. doi: 10.7759/cureus.17059. eCollection 2021 Aug.
Pulmonary angiosarcomas (PAS) are rare malignant vascular tumors that due to their aggressive and metastatic nature, are often diagnosed at a late stage, resulting in a poorer prognosis. Here we present a 53-year-old male who was initially found to have recurring episodes of dyspnea and syncope, with initial workup showing bilateral saddle pulmonary embolisms on computerized tomography, presumed secondary to newly discovered atrial fibrillation with sinus node dysfunction. Further investigation over subsequent months and subsequent biopsy of a potential lung mass ultimately revealed pulmonary angiosarcoma of the spindle cell line. This case emphasizes findings in the current literature, which reveal the time between the onset of symptoms and definitive diagnosis ranges from two to six months, with a median survival time of seven months or two months, with solitary lesions or multiple lesions at the time of diagnosis, respectively. With the limited incidence of PAS, this case suggests benefits in the development of screening and detection criteria for earlier detection and treatment.
肺血管肉瘤（PAS）是罕见的恶性血管肿瘤，由于其侵袭性和转移性，常常在晚期才被诊断出来，导致预后较差。在此，我们报告一名53岁男性，最初发现其有反复发作的呼吸困难和晕厥，初步检查显示计算机断层扫描发现双侧鞍状肺栓塞，推测继发于新发现的伴有窦房结功能障碍的心房颤动。在随后的几个月里进一步检查以及对一个潜在肺部肿块进行活检，最终确诊为梭形细胞型肺血管肉瘤。该病例强调了当前文献中的研究结果，即症状出现到明确诊断的时间为2至6个月，中位生存时间分别为7个月（诊断时有孤立性病变）或2个月（诊断时有多个病变）。鉴于PAS发病率有限，该病例提示制定筛查和检测标准以实现早期发现和治疗具有益处。
