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抗生素联合手术肺切除治疗乳腺癌患者肺部感染

Combination treatment with antibiotics and surgical lung resection for pulmonary infection in a breast cancer patient.

作者信息

Tokuyasu Hirokazu, Makino Yoshinari, Kubouchi Yasuaki, Miwa Ken, Miura Hiroshi, Ishikawa Soichiro, Sakai Hiromitsu, Yamasaki Akira

机构信息

Division of Respiratory Medicine, Matsue Red Cross Hospital, Shimane, Japan.

Division of Breast Surgery, Matsue Red Cross Hospital, Shimane, Japan.

出版信息

Respir Med Case Rep. 2021 Sep 3;34:101506. doi: 10.1016/j.rmcr.2021.101506. eCollection 2021.

DOI:10.1016/j.rmcr.2021.101506
PMID:34522602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8427237/
Abstract

A 51-year-old woman was admitted to our hospital because of pneumonia after chemotherapy with doxorubicin and cyclophosphamide for left breast cancer. The patient was diagnosed with pulmonary infection by the detection of complex (MABC) in sputum cultures. However, MABC is intrinsically resistant to most of the antibacterial agents, and MABC pulmonary disease outcomes with modern antibiotic treatment are currently the worst among all mycobacterial species. We herein report the successful treatment of pulmonary infection by a combination treatment with antibiotics and surgical lung resection.

摘要

一名51岁女性因左乳腺癌接受阿霉素和环磷酰胺化疗后发生肺炎而入住我院。通过痰培养检测到复杂性非结核分枝杆菌(MABC),该患者被诊断为肺部感染。然而,MABC对大多数抗菌药物具有内在抗性,并且在现代抗生素治疗下,MABC肺部疾病的预后目前在所有分枝杆菌种类中是最差的。我们在此报告通过抗生素联合手术肺切除成功治疗肺部感染的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/a1d7c7ca5028/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/33e34b925d81/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/1c993a019d2b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/c11a85263a20/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/a1d7c7ca5028/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/33e34b925d81/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/1c993a019d2b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/c11a85263a20/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f88b/8427237/a1d7c7ca5028/gr4.jpg

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本文引用的文献

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Clinico-microbiological analysis of 121 patients with pulmonary Mycobacteroides abscessus complex disease in Japan - An NTM-JRC study with RIT.日本 121 例肺部脓肿分枝杆菌复合体病的临床微生物学分析——一项 RIT 参与的 NTM-JRC 研究
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Systematic Review and Meta-analyses of the Effect of Chemotherapy on Pulmonary Mycobacterium abscessus Outcomes and Disease Recurrence.系统评价和荟萃分析化疗对肺部脓肿分枝杆菌结局和疾病复发的影响。
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Chest. 2017 Jul;152(1):120-142. doi: 10.1016/j.chest.2017.04.166. Epub 2017 Apr 28.
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Analysis of the impact of lung cancer treatment on nontuberculous mycobacterial lung diseases.肺癌治疗对非结核分枝杆菌肺病影响的分析
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Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense.脓肿分枝杆菌和马赛分枝杆菌肺病的进展和治疗结果。
Clin Infect Dis. 2017 Feb 1;64(3):301-308. doi: 10.1093/cid/ciw723. Epub 2016 Nov 10.
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Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease.分枝杆菌特点和脓肿分枝杆菌肺病的治疗结果。
Clin Infect Dis. 2017 Feb 1;64(3):309-316. doi: 10.1093/cid/ciw724. Epub 2016 Nov 10.
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Emended description of Mycobacterium abscessus, Mycobacterium abscessus subsp. abscessus and Mycobacteriumabscessus subsp. bolletii and designation of Mycobacteriumabscessus subsp. massiliense comb. nov.脓肿分枝杆菌、脓肿分枝杆菌脓肿亚种和博莱蒂分枝杆菌脓肿亚种的修订描述以及马赛分枝杆菌脓肿亚种的命名(新组合)
Int J Syst Evol Microbiol. 2016 Nov;66(11):4471-4479. doi: 10.1099/ijsem.0.001376. Epub 2016 Aug 4.
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Analysis of pulmonary non-tuberculous mycobacterial infections after lung transplantation.肺移植术后肺部非结核分枝杆菌感染的分析
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