Jacoub Khaldun, Abdelfattah Ali
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa 13133, Jordan.
European Cancer Stem Cell Research Institute, Cardiff University, School of Biosciences, Cardiff, UK.
J Clin Med Res. 2025 Jul 31;17(7):357-364. doi: 10.14740/jocmr6276. eCollection 2025 Jul.
The ABO and Rhesus blood systems have been studied extensively in relation to various diseases, including cancers. Recent evidence suggests that ABO blood group may influence susceptibility to oral potentially malignant disorders (OPMDs) and oral cancers, particularly oral squamous cell carcinoma (OSCC). The current review explores the association of ABO and Rhesus blood groups with oral cancers, summarizing epidemiological, molecular, and immunological studies to elucidate potential mechanisms underlying this relationship.
ABO和恒河猴血型系统已针对包括癌症在内的各种疾病进行了广泛研究。最近的证据表明,ABO血型可能会影响口腔潜在恶性疾病(OPMD)和口腔癌,尤其是口腔鳞状细胞癌(OSCC)的易感性。本综述探讨了ABO和恒河猴血型与口腔癌的关联,总结了流行病学、分子和免疫学研究,以阐明这种关系背后的潜在机制。