深部脑刺激能否改善帕金森病相关的下尿路症状及排尿功能障碍？
Does deep brain stimulation improve Parkinson's disease-related lower urinary tract symptoms and voiding dysfunction?
作者信息
Tabakin Alexandra L, Tunuguntla Hari S G R
机构信息
Division of Urology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
出版信息
Bladder (San Franc). 2021 Aug 27;8(2):e46. doi: 10.14440/bladder.2021.825. eCollection 2021.
Abstract
Parkinson's disease (PD), caused by degeneration of dopaminergic neurons, leads to motor and autonomic symptoms. A large proportion of PD patients experience lower urinary tract symptoms (LUTS) and voiding dysfunction, associated with poor quality of life. Deep brain stimulation (DBS) is an adjunctive therapy used in combination with medication for Parkinsonian motor symptoms and is currently being explored to treat PD-related LUTS. This review discusses the current literature on the effects of DBS on lower urinary tract function and whether this modality can be used to modulate PD-related LUTS and voiding dysfunction.
摘要
帕金森病（PD）由多巴胺能神经元变性引起，会导致运动和自主神经症状。很大一部分帕金森病患者会出现下尿路症状（LUTS）和排尿功能障碍，这与生活质量差有关。深部脑刺激（DBS）是一种与药物联合用于治疗帕金森运动症状的辅助疗法，目前正在探索其用于治疗帕金森病相关下尿路症状的可能性。本文综述讨论了关于深部脑刺激对下尿路功能影响的现有文献，以及这种治疗方式是否可用于调节帕金森病相关下尿路症状和排尿功能障碍。
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本文引用的文献
1
Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease.帕金森病患者膀胱过度活动症症状的尿动力学机制
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Urinary symptoms are correlated with quality of life after deep brain stimulation in Parkinson's disease.排尿症状与帕金森病深部脑刺激后的生活质量相关。
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Locus Coeruleus atrophy doesn't relate to fatigue in Parkinson's disease.蓝斑萎缩与帕金森病的疲劳无关。
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Brain activation during the voiding phase of micturition in healthy adults: A meta-analysis of neuroimaging studies.健康成年人排尿期的脑激活：神经影像学研究的荟萃分析
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Feasibility of deep brain stimulation for controlling the lower urinary tract functions: An animal study.深部脑刺激控制下尿路功能的可行性：一项动物研究。
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Adverse events in deep brain stimulation: A retrospective long-term analysis of neurological, psychiatric and other occurrences.脑深部电刺激的不良事件：对神经、精神及其他事件的回顾性长期分析
PLoS One. 2017 Jul 5;12(7):e0178984. doi: 10.1371/journal.pone.0178984. eCollection 2017.
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