Gerber L M, Madhavan S, Alderman M H
Department of Public Health, Cornell University Medical College, New York, NY 10021.
Am J Prev Med. 1987 Mar-Apr;3(2):64-8.
Participants in a systematic antihypertensive care program were examined to determine whether the site of fat predominance--measured by the waist-to-hip ratio--is related to hyperglycemia in patients taking diuretics. Among 1,044 hypertensive patients meeting a set of selection criteria, 22 men who developed hyperglycemia during a mean treatment period of 25.6 months were identified and individually matched for age, race, body mass index, and duration of diuretic treatment to a comparable group of hypertensive patients who remained normoglycemic. The mean waist-to-hip ratio was higher among the hyperglycemic men, although this difference did not reach conventional levels of statistical significance. However, a significantly greater proportion of the hyperglycemic men than those who were normoglycemic fell into a higher ratio category when waist-to-hip ratios were classified according to whether they were less than or greater than or equal to 0.90. When the ratios were examined in relation to body mass index, the greatest difference between the two groups was observed in the leanest group. This study suggests that the waist-to-hip ratio, in conjunction with total body fatness, may be an important tool for distinguishing persons with hypertension who may develop hyperglycemia when treated with diuretics.
对参与一项系统性降压护理项目的患者进行了检查，以确定通过腰臀比测量的脂肪优势部位是否与服用利尿剂的患者的高血糖有关。在1044名符合一组入选标准的高血压患者中，识别出22名在平均25.6个月的治疗期内出现高血糖的男性，并将其按年龄、种族、体重指数和利尿剂治疗时长与一组血糖正常的高血压患者进行个体匹配。高血糖男性的平均腰臀比更高，尽管这种差异未达到传统的统计学显著水平。然而，当根据腰臀比是否小于或大于或等于0.90进行分类时，高血糖男性中处于较高比例类别的人数显著多于血糖正常的男性。当将这些比例与体重指数相关联进行检查时，在最瘦的组中观察到两组之间的最大差异。这项研究表明，腰臀比与总体脂肪量相结合，可能是区分在用利尿剂治疗时可能出现高血糖的高血压患者的重要工具。
