Institute of Natural and Sythetic Organic Chemistry, Changzhou University, Changzhou 213164, China.
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Org Lett. 2021 Oct 1;23(19):7561-7565. doi: 10.1021/acs.orglett.1c02757. Epub 2021 Sep 15.
This work describes an efficient Pd-catalyzed indole synthesis. A wide variety of indoles can be obtained in good yields from readily available vinyl bromides. The reaction likely proceeds through a sequential aryl C-H activation and bisamination of a resulting pallada(II)cycle with diaziridinone.
这项工作描述了一种高效的钯催化吲哚合成方法。从易得的乙烯基溴化物可以得到多种吲哚，产率良好。该反应可能通过芳基 C-H 活化的顺序和钯(II)环与重氮甲烷的双胺化反应进行。
