Institute of Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou 213164, China.
Department of Chemistry, Colorado State University, Fort Collins 80523, Colorado, United States.
Org Lett. 2021 May 7;23(9):3646-3651. doi: 10.1021/acs.orglett.1c01043. Epub 2021 Apr 16.
Indoles are an important class of molecules. This paper describes an efficient palladium-catalyzed synthesis of indoles from 2-iodostyrenes and di--butyldiaziridinone with a simultaneous installation of two C-N bonds. The reaction process likely proceeds through the oxidative insertion of Pd to aryl iodide and subsequent vinyl C-H activation to from a pallada(II)cycle intermediate, which is bisaminated by di--butyldiaziridinone to give the indole product.
吲哚是一类重要的分子。本文描述了一种高效的钯催化合成吲哚的方法，该方法由 2-碘代苯乙烯和二丁基二氮杂环丁酮通过同时构建两个 C-N 键得到。反应过程可能是通过钯对芳基碘化物的氧化插入，以及随后的乙烯 C-H 活化，形成钯(II)环中间体，然后由二丁基二氮杂环丁酮对其进行双氨基化，得到吲哚产物。
