Guerron Alberto, Giasson Suzanne
Faculty of Pharmacy, Université de Montréal, C. P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.
Department of Chemistry, Université de Montréal, C. P. 6128, Succursale Centre-Ville, Montréal, Québec H3C 3J7, Canada.
Langmuir. 2021 Sep 28;37(38):11212-11221. doi: 10.1021/acs.langmuir.1c01269. Epub 2021 Sep 15.
Dual-responsive poly-(-isopropylacrylamide) (PNIPAM) microgels surface-functionalized with polyethylene glycol (PEG) or poly-2-dimethylaminoethyl methacrylate (PDMAEMA) were developed to enable the swelling behavior and surface properties of the microgels to be tuned independently. The thermo-triggered swelling and pH-triggered surface properties of the microgels were investigated in aqueous suspensions using dynamic light scattering and on substrates using the surface forces apparatus. Grafting polymer chains on the microgel surface did not impede the thermo-triggered swelling behavior of the microgels in suspensions and immobilized on substrates. An unprecedented decoupling of the swelling behavior and surface properties could be obtained. More particularly, the thermo-triggered swelling behavior of the PNIPAM underlying microstructure could be tuned below and above the phase transition temperature with no change in the surface potential and adhesion provided by the surface non-responsive PEG.
开发了用聚乙二醇（PEG）或聚甲基丙烯酸2-二甲氨基乙酯（PDMAEMA）进行表面功能化的双响应聚（N-异丙基丙烯酰胺）（PNIPAM）微凝胶，以使微凝胶的溶胀行为和表面性质能够独立调节。使用动态光散射在水悬浮液中以及使用表面力仪在基底上研究了微凝胶的热触发溶胀和pH触发表面性质。在微凝胶表面接枝聚合物链并不妨碍微凝胶在悬浮液中的热触发溶胀行为，且微凝胶能固定在基底上。可以实现溶胀行为和表面性质前所未有的解耦。更具体地说，在低于和高于相变温度时，可以调节PNIPAM底层微观结构的热触发溶胀行为，而由表面无响应的PEG提供的表面电位和粘附力不变。
