吲哚、吡咯和呋喃在蓝色 LED 照射下与碘𬭩叶立德的可持续 C-H 功能化反应。
A sustainable C-H functionalization of indoles, pyrroles and furans under a blue LED with iodonium ylides.
机构信息
Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Chithera, Dadri, Gautam Buddha Nagar, UP 201314, India.
School of Engineering and Architecture, Institute of Chemical Technology at University of Applied Sciences and Arts of Western Switzerland, CH-1700 Fribourg, Switzerland.
出版信息
Org Biomol Chem. 2021 Sep 15;19(35):7627-7632. doi: 10.1039/d1ob01219c.
Pyrrole and indole derivatives are functionalized a green initiative with the dimethyl malonate derived phenyl iodonium ylide 4a in the presence of a blue LED C-H functionalization of the respective heterocycles in methanol to generate the desired compounds 5-7 in moderate to good yields. Control experiments provide insight into the probable reaction mechanism. Finally, the strategy is successfully applied in the generation of azepino[4,5-]indole 12a/b.
吡咯和吲哚衍生物在蓝色 LED 存在下，用二甲丙二酸衍生的苯基碘翁盐 4a 进行功能化，是一种绿色倡议，在甲醇中对各自的杂环进行 C-H 功能化，以中等至良好的收率生成所需的化合物 5-7。对照实验提供了对可能的反应机制的深入了解。最后，该策略成功应用于氮杂[4,5-]吲哚 12a/b 的生成。
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