Souza Ronei M S, Goulart Tales A C, Pinheiro Roberto do C, Sonaglio Felipe F do C, Simoni Deborah de A, Cormanich Rodrigo A, Jurberg Igor D
Department of Organic Chemistry, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.
Institutional X-Ray Laboratory, Institute of Chemistry, State University of Campinas, Rua Monteiro Lobato 270, 13083-862, Campinas, SP, Brazil.
Chem Asian J. 2025 Aug;20(16):e00455. doi: 10.1002/asia.202500455. Epub 2025 May 13.
This work describes a protocol being only promoted by visible light for the C3-alkylation of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines with aryldiazoacetates. Several known and new analogs of a key intermediate employed in previous syntheses of zolpidem have been accessed in good yields. The preparation of this key intermediate was also achieved using this method, but an adjustment of the nature of the alkylating agent was required.
这项工作描述了一种仅通过可见光促进咪唑并[1,2 - a]嘧啶和咪唑并[1,2 - a]吡啶与芳基重氮乙酸酯进行C3 - 烷基化反应的方法。在唑吡坦先前合成中使用的关键中间体的几种已知和新的类似物均以良好的产率得到。使用该方法也实现了这种关键中间体的制备，但需要调整烷基化剂的性质。
