Institute of Applied Chemistry, Central South University of Forestry and Technology, Changsha, 410004, China.
School of Materials and Chemical Engineering, Hunan Provincial Key Laboratory of Environmental Catalysis & Waste Recycling, Hunan Institute of Engineering, Xiangtan, 411104, China.
Org Biomol Chem. 2021 Sep 15;19(35):7602-7606. doi: 10.1039/d1ob01405f.
An efficient palladium-catalyzed difunctionalization/dearomatization of -benzylacrylamides with α-carbonyl alkyl bromides as alkyl radical precursors has been described. Various α-carbonyl alkyl bromides, including α-bromoalkyl esters and ketones, reacted smoothly to provide important azaspirocyclohexadienones in moderate to excellent yields. In addition, mechanistic studies suggested that the reaction proceeded a radical pathway.
本文描述了一种高效的钯催化 - 苄基丙烯酰胺与α-羰基烷基溴化物（作为烷基自由基前体）的双官能化/去芳构化反应。各种α-羰基烷基溴化物，包括α-溴代酯和酮，都能顺利反应，以中等至优异的收率得到重要的氮杂螺环[3.4]辛二烯酮。此外，机理研究表明该反应经过自由基途径进行。
