Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul, Korea.
Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.
Epidemiol Health. 2021;43:e2021063. doi: 10.4178/epih.e2021063. Epub 2021 Sep 8.
Data on associations between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Therefore, this study aimed to explore the associations between a normal BT range (35.0-37.5°C) and LTL via 6-year longitudinal observations of 2,004 male and female adults aged 50 or older.
BT was obtained by measuring the tympanic temperature, and relative LTL was determined by real-time polymerase chain reaction. Robust regression analysis was used to evaluate the association between the baseline and follow-up LTL values and their differences.
A significant inverse association was found between BT and LTL at baseline. The regression coefficient estimate was -0.03 (95% confidence interval, -0.07 to -0.001; p<0.05). This association was stronger in participants with a body mass index >25 kg/m2 and males (p<0.01). However, there were no associations between BT and LTL at follow-up or BT and 6-year longitudinal differences in LTL.
These findings suggest that having a high BT between 35°C and 37.5°C (95°F and 99°F) may be detrimental for obese individuals in terms of biological aging.
在最近的流行病学研究中，白细胞端粒长度（LTL）已被广泛用作细胞衰老的生物标志物，但关于体温（BT）与 LTL 之间关联的数据有限。因此，本研究旨在通过对 2004 名 50 岁及以上男女成年人进行为期 6 年的纵向观察，探讨正常 BT 范围（35.0-37.5°C）与 LTL 之间的关联。
通过测量鼓膜温度获得 BT，通过实时聚合酶链反应测定相对 LTL。采用稳健回归分析评估基线和随访 LTL 值及其差异之间的关联。
在基线时，BT 与 LTL 呈显著负相关。回归系数估计值为-0.03（95%置信区间：-0.07 至 -0.001；p<0.05）。在 BMI>25 kg/m2 和男性参与者中，这种关联更强（p<0.01）。然而，在随访时或 BT 与 LTL 6 年纵向差异之间均未观察到 BT 与 LTL 之间存在关联。
这些发现表明，在 35°C 至 37.5°C（95°F 至 99°F）之间保持较高的 BT 可能对肥胖个体的生物衰老不利。
