Department of Neurosurgery, Hanyang University Guri Hospital, Guri 11923, South Korea.
Department of Neurology, Hanyang University Guri Hospital, Guri 11923, South Korea.
Aging (Albany NY). 2024 Jul 25;16(14):11151-11161. doi: 10.18632/aging.206034.
A shorter leukocyte telomere length (LTL) is reported to be associated with age-related diseases, including osteoporosis. Many studies have tried identifying the association between LTL and osteoporosis, although it remains controversial. This study aimed to determine whether osteoporosis is independently associated with LTL shortening in a prospective longitudinal cohort. The KBASE study is an independent multicenter prospective cohort in South Korea, which began in 2014. We compared the LTL values for each participant at baseline and over a 2-year follow-up period. Boxplots were used to demonstrate the differences in the change in LTL over a 2-year follow-up according to osteoporosis. Multivariable linear regression was conducted to identify whether osteoporosis is independently associated with the rate of telomere shortening. A total of 233 subjects (from 55 to 88 years) from the KBASE cohort were finally enrolled in the study. We observed that the LTL decreased by approximately 1.2 kbp over 2 years. While the LTL decreased as age increased, the rate of LTL shortening did not increase with age. Multivariable linear regression analysis indicated that only osteoporosis was independently associated with rapid LTL shortening over 2 years (B, -8.08; p = 0.038). We sought to identify an association between osteoporosis and LTL shortening in an independent prospective cohort. We found that participants with osteoporosis had significantly faster LTL shortening over 2 years than those without osteoporosis. We hope this study will help elucidate the underlying mechanisms in the relationship between LTL and osteoporosis in the future.
据报道，较短的白细胞端粒长度（LTL）与年龄相关的疾病有关，包括骨质疏松症。许多研究试图确定 LTL 与骨质疏松症之间的关联，但结果仍存在争议。本研究旨在确定骨质疏松症是否与前瞻性纵向队列中 LTL 缩短独立相关。KBASE 研究是韩国的一项独立多中心前瞻性队列研究，始于 2014 年。我们比较了每个参与者在基线时和 2 年随访期间的 LTL 值。箱线图用于显示根据骨质疏松症，2 年随访期间 LTL 变化的差异。采用多变量线性回归来确定骨质疏松症是否与端粒缩短率独立相关。最终，从 KBASE 队列中招募了 233 名（年龄 55-88 岁）受试者参与本研究。我们观察到，在 2 年内，LTL 大约缩短了 1.2 kbp。虽然 LTL 随着年龄的增长而降低，但 LTL 缩短的速度并没有随年龄的增长而增加。多变量线性回归分析表明，只有骨质疏松症与 2 年内 LTL 快速缩短独立相关（B，-8.08；p = 0.038）。我们试图在独立的前瞻性队列中确定骨质疏松症与 LTL 缩短之间的关联。我们发现，患有骨质疏松症的参与者在 2 年内 LTL 缩短的速度明显快于没有骨质疏松症的参与者。我们希望本研究将有助于阐明未来 LTL 与骨质疏松症之间关系的潜在机制。
