Guisado Francisco Rodríguez, Castro Pedro Luis
University of Las Palmas de Gran Canaria, Arucas, Gran Canaria, Spain.
Vet Pathol. 2022 Jan;59(1):57-62. doi: 10.1177/03009858211042582. Epub 2021 Sep 16.
This study describes the histomorphology and immunohistochemical profile of 9 cases of feline piloleiomyosarcoma. Cats ranged in age from 7 to 16 years (mean 10), and tumors were 7 to 24 mm in diameter (mean 15). Tumors were composed of fusiform cells that were haphazardly arranged or in variably sized interwoven bundles. Neoplastic cells had eosinophilic and fibrillar cytoplasm, and elongated blunt-ended nuclei. Entrapment of hair follicles and absence of vascular components support an origin from the smooth muscle cells of the arrector pili. Additional findings included bizarre nuclei and giant cells (7/9 cases), atypical mitoses (7/9 cases), ulceration (3/9 cases), and intratumoral necrosis (6/9 cases). Neoplastic cells expressed calponin, desmin, α-smooth muscle actin, and vimentin, but not CD18, CD31, cytokeratins, glial fibrillary acidic protein, neuron-specific enolase, Melan A, p63, or S-100 protein. Surgical excision was curative in 6/9 cases, with local recurrence in 2/9 cases and metastasis to local lymph nodes in 1/9 case. Clinical outcome was influenced by mitotic count, infiltration of subcutaneous tissue, and intensity of nuclear immunolabeling for p53.
本研究描述了9例猫毛平滑肌肉瘤的组织形态学和免疫组化特征。猫的年龄在7至16岁之间（平均10岁），肿瘤直径为7至24毫米（平均15毫米）。肿瘤由梭形细胞组成，这些细胞排列杂乱或形成大小不一的交织束状。肿瘤细胞具有嗜酸性和纤维状细胞质，以及细长的钝端核。毛囊包埋和无血管成分支持其起源于立毛肌的平滑肌细胞。其他发现包括奇异核和巨细胞（7/9例）、非典型有丝分裂（7/9例）、溃疡形成（3/9例）和肿瘤内坏死（6/9例）。肿瘤细胞表达钙调蛋白、结蛋白、α平滑肌肌动蛋白和波形蛋白，但不表达CD18、CD31、细胞角蛋白、胶质纤维酸性蛋白、神经元特异性烯醇化酶、黑素A、p63或S-100蛋白。9例中有6例手术切除治愈，2例局部复发，1例转移至局部淋巴结。临床结果受有丝分裂计数、皮下组织浸润和p53核免疫标记强度的影响。
