Cancer Institue, Affiliated People's Hospital of Jiangsu University, No 8, Dianli Road, Zhenjiang, Jiangsu Province, 212002, People's Republic of China.
Department of Gastroenterology, Affiliated Suqian First People's Hospital of Nanjing Medical University, No 120, Suzhi Road, Suqian, Jiangsu Province, 223812, People's Republic of China.
Mol Cancer. 2021 Sep 15;20(1):119. doi: 10.1186/s12943-021-01417-4.
Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation.
环状 RNA 是一种共价闭合的 RNA，广泛存在于真核生物中。CircRNAs 参与多种生理和病理过程，但它们的调控机制尚不完全清楚。鉴于 RNA 深度测序技术的发展和算法的改进，一些 CircRNAs 被发现通过非依赖帽的机制编码蛋白质，并参与肿瘤发生和发展的重要过程。本文通过对 CircRNAs 的综述，总结了其翻译机制和研究方法，并回顾了近年来 CircRNAs 翻译在肿瘤学领域的研究进展。此外，本文旨在通过 CircRNAs 翻译为肿瘤的诊断和治疗提供新的思路。
