氟虫腈/(S)-甲氧普烯/依普菌素/吡喹酮（宽线）对自然感染眼线虫的猫的疗效。
Efficacy of fipronil/(S)-methoprene/eprinomectin/praziquantel (Broadline) against Thelazia callipaeda in naturally infected cats.
机构信息
Department of Veterinary Sciences, University of Turin, Turin, Italy.
Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.
出版信息
Parasit Vectors. 2021 Sep 15;14(1):477. doi: 10.1186/s13071-021-04983-0.
BACKGROUND
The present clinical field trial was conducted to assess the efficacy of a broad-spectrum parasiticide spot-on formulation containing eprinomectin (Broadline) against Thelazia callipaeda eyeworm in naturally infected cats.
METHODS
Fifteen privately owned cats harboring at least one live adult T. callipaeda were included in the study. Cats were randomly allocated to an untreated control group of seven cats or to a Broadline-treated group of eight cats. Cats were treated on Day 0; ocular examinations were performed at inclusion and on Days 7 and 14; eyeworms were recovered and counted on Day 14. The primary efficacy assessment was based on group comparison of number of T. callipaeda on Day 14.
RESULTS
Seven days after treatment, six of eight treated cats were negative for eyeworm infection per visual examination, and on Day 14 no eyeworms were found in the treated cats while the seven untreated cats were still infected (geometric mean: 1.97). All cats had inflammatory ocular signs at inclusion; on Day 14, five of eight treated cats had recovered while all untreated control cats were still symptomatic. All collected parasites were confirmed to be T. callipaeda by morphology and molecular characterization.
CONCLUSIONS
A single treatment with Broadline provided 100% efficacy against feline thelaziosis and improved related ocular inflammation signs.
背景
本临床现场试验旨在评估含有埃普菌素（Broadline）的广谱杀寄生虫滴剂配方对自然感染犬首线虫的疗效。
方法
15 只私人拥有的猫至少携带一只活成虫犬首线虫被纳入研究。猫被随机分配到未治疗的对照组（7 只猫）或 Broadline 治疗组（8 只猫）。猫在第 0 天接受治疗；在纳入时以及第 7 天和第 14 天进行眼部检查；在第 14 天回收并计数眼线虫。主要疗效评估基于第 14 天眼线虫数量的组间比较。
结果
治疗后 7 天，8 只治疗猫中有 6 只通过视觉检查呈眼线虫感染阴性，而在第 14 天，治疗猫中未发现眼线虫，而未治疗的 7 只对照猫仍被感染（几何均数：1.97）。所有猫在纳入时均有眼部炎症体征；在第 14 天，8 只治疗猫中有 5 只已康复，而所有未治疗的对照猫仍有症状。所有收集的寄生虫均通过形态学和分子特征鉴定为犬首线虫。
结论
单次使用 Broadline 对猫的眼线虫病提供了 100%的疗效，并改善了相关的眼部炎症体征。
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