Knaus Martin, Capári Balázs, Visser Martin
Merial GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany,
Parasitol Res. 2014 Nov;113(11):4303-6. doi: 10.1007/s00436-014-4126-z. Epub 2014 Sep 26.
The efficacy of a novel topical combination of fipronil 8.3% w/v, (S)-methoprene 10 % w/v, eprinomectin 0.4% w/v, and praziquantel 8.3% w/v (Broadline, Merial) was evaluated in 18 cats naturally infested by Notoedres cati in a controlled, blinded clinical efficacy study. Cats were blocked on pretreatment bodyweight and randomly allocated to two groups of nine cats each. One group served as control (untreated) and one group was treated once topically with Broadline according to the label instructions. Skin scrapings (three scrapings per animal per occasion) were collected prior to treatment and every other week for 8 weeks thereafter and examined for live N. cati mites. In addition, lesions were evaluated at each sampling to monitor the clinical recovery. Based on live mite counts, efficacy against N. cati of a single topical administration with Broadline was >99%, and all treated cats recovered from clinical signs of notoedric mange. No treatment-related adverse events were observed.
在一项对照、盲法临床疗效研究中，对18只自然感染猫背肛螨的猫进行了评估，以确定含8.3%（重量/体积）氟虫腈、10%（重量/体积）（S）-烯虫酯、0.4%（重量/体积）埃普利诺菌素和8.3%（重量/体积）吡喹酮的新型局部用复方制剂（博来恩，梅里亚公司）的疗效。根据预处理体重对猫进行分组，并随机分为两组，每组9只猫。一组作为对照（未治疗），另一组按照标签说明用博来恩进行一次局部治疗。在治疗前以及之后的8周内每隔一周采集皮肤刮屑（每只动物每次刮取三处），检查是否存在活的猫背肛螨。此外，在每次采样时对病变进行评估，以监测临床恢复情况。根据活螨计数，单次局部使用博来恩对猫背肛螨的疗效>99%，所有接受治疗的猫均从背肛螨疥癣的临床症状中恢复。未观察到与治疗相关的不良事件。
