• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过阻断对缺氧的适应来“窒息”肿瘤：黑色素瘤免疫治疗的新进展

"Suffocating" tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy.

作者信息

Janji Bassam, Chouaib Salem

机构信息

Tumor Immunotherapy and Microenvironment (TIME) Group, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg City, Luxembourg.

Inserm Umr 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Villejuif, France.

出版信息

Oncoimmunology. 2021 Sep 7;10(1):1968611. doi: 10.1080/2162402X.2021.1968611. eCollection 2021.

DOI:10.1080/2162402X.2021.1968611
PMID:34527430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8437449/
Abstract

We recently reported that inhibiting Hypoxia-inducible Factor-1α () transcriptional activity improves melanoma immunotherapy by driving immune cells into the tumor microenvironment (TME). This Author's View provides additional perspectives on how hypoxia inhibitors combined with immunotherapy can be used as innovative approaches to improve the therapeutic benefit of melanoma patients.

摘要

我们最近报道，抑制缺氧诱导因子-1α（HIF-1α）的转录活性可通过促使免疫细胞进入肿瘤微环境（TME）来改善黑色素瘤免疫治疗。本作者观点提供了关于缺氧抑制剂与免疫治疗联合使用如何作为创新方法来提高黑色素瘤患者治疗益处的更多观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d1c/8437449/e36ddbea504f/KONI_A_1968611_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d1c/8437449/e36ddbea504f/KONI_A_1968611_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d1c/8437449/e36ddbea504f/KONI_A_1968611_F0001_OC.jpg

相似文献

1
"Suffocating" tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapy.通过阻断对缺氧的适应来“窒息”肿瘤：黑色素瘤免疫治疗的新进展
Oncoimmunology. 2021 Sep 7;10(1):1968611. doi: 10.1080/2162402X.2021.1968611. eCollection 2021.
2
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy.靶向 HIF-1α转录活性可促使细胞毒性免疫效应细胞浸润黑色素瘤并改善联合免疫治疗。
Oncogene. 2021 Jul;40(28):4725-4735. doi: 10.1038/s41388-021-01846-x. Epub 2021 Jun 21.
3
Firing up the cold tumors by targeting Vps34.通过靶向Vps34激活冷肿瘤
Oncoimmunology. 2020 Aug 31;9(1):1809936. doi: 10.1080/2162402X.2020.1809936.
4
Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34.通过阻断自噬相关蛋白 PIK3C3/VPS34 的活性来点燃冷肿瘤中的火，以改善癌症免疫疗法。
Autophagy. 2020 Nov;16(11):2110-2111. doi: 10.1080/15548627.2020.1815439. Epub 2020 Sep 5.
5
The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality?靶向缺氧改善癌症免疫治疗的前景：是虚幻还是现实？
Front Immunol. 2022 Jun 20;13:880810. doi: 10.3389/fimmu.2022.880810. eCollection 2022.
6
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.抑制Vps34可将冷肿瘤重编程为热炎症性肿瘤，并改善抗PD-1/PD-L1免疫疗法。
Sci Adv. 2020 Apr 29;6(18):eaax7881. doi: 10.1126/sciadv.aax7881. eCollection 2020 May.
7
Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.黑色素瘤研究的未来展望：“黑色素瘤桥梁”会议报告：那不勒斯，2014年12月3日至6日
J Transl Med. 2015 Nov 30;13:374. doi: 10.1186/s12967-015-0736-1.
8
Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma.肿瘤细胞氧化代谢作为黑色素瘤 PD-1 阻断免疫治疗的障碍。
JCI Insight. 2019 Mar 7;4(5). doi: 10.1172/jci.insight.124989.
9
Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy.针对肿瘤微环境中的缺氧：提高癌症免疫疗法的潜在策略。
J Exp Clin Cancer Res. 2021 Jan 9;40(1):24. doi: 10.1186/s13046-020-01820-7.
10
Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment.联合阻断 IL6 和 PD-1/PD-L1 信号通路可消除肿瘤微环境中它们免疫抑制作用的相互调节。
Cancer Res. 2018 Sep 1;78(17):5011-5022. doi: 10.1158/0008-5472.CAN-18-0118. Epub 2018 Jul 2.

引用本文的文献

1
Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy.黑色素瘤中的免疫逃逸和转移机制：打破二分法。
Front Immunol. 2024 Feb 14;15:1336023. doi: 10.3389/fimmu.2024.1336023. eCollection 2024.
2
Combined pembrolizumab and bevacizumab therapy effectively inhibits non-small-cell lung cancer growth and prevents postoperative recurrence and metastasis in humanized mouse model.帕博利珠单抗联合贝伐珠单抗治疗有效抑制非小细胞肺癌生长并预防人源化小鼠模型术后复发和转移。
Cancer Immunol Immunother. 2023 May;72(5):1169-1181. doi: 10.1007/s00262-022-03318-x. Epub 2022 Nov 10.
3
Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy.

本文引用的文献

1
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy.靶向 HIF-1α转录活性可促使细胞毒性免疫效应细胞浸润黑色素瘤并改善联合免疫治疗。
Oncogene. 2021 Jul;40(28):4725-4735. doi: 10.1038/s41388-021-01846-x. Epub 2021 Jun 21.
2
MIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanoma.抑制巨噬细胞移动抑制因子作为克服黑色素瘤对免疫检查点阻断疗法耐药性的一种策略。
Oncoimmunology. 2020 Dec 6;9(1):1846915. doi: 10.1080/2162402X.2020.1846915.
3
The role of hypoxia-inducible factor 1 in tumor immune evasion.
试验观察：酪氨酸激酶抑制剂（TKIs）与免疫疗法联合应用。
Oncoimmunology. 2022 May 26;11(1):2077898. doi: 10.1080/2162402X.2022.2077898. eCollection 2022.
缺氧诱导因子 1 在肿瘤免疫逃逸中的作用。
Med Res Rev. 2021 May;41(3):1622-1643. doi: 10.1002/med.21771. Epub 2020 Dec 11.
4
Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy.抑制Vps34可将冷肿瘤重编程为热炎症性肿瘤，并改善抗PD-1/PD-L1免疫疗法。
Sci Adv. 2020 Apr 29;6(18):eaax7881. doi: 10.1126/sciadv.aax7881. eCollection 2020 May.
5
Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer.缺氧应激：癌症创新免疫疗法的障碍与机遇
Oncogene. 2017 Jan 26;36(4):439-445. doi: 10.1038/onc.2016.225. Epub 2016 Jun 27.
6
Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching.缺氧通过触发 HIF1α 依赖性表型转换促进黑色素瘤异质性。
J Invest Dermatol. 2013 Oct;133(10):2436-2443. doi: 10.1038/jid.2013.115. Epub 2013 Mar 8.
7
Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy.针对缺氧、HIF-1 和肿瘤葡萄糖代谢来提高放疗疗效。
Clin Cancer Res. 2012 Oct 15;18(20):5585-94. doi: 10.1158/1078-0432.CCR-12-0858.
8
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression.阻断肿瘤缺氧诱导的自噬可恢复细胞毒性 T 细胞的活性并促进肿瘤消退。
Cancer Res. 2011 Sep 15;71(18):5976-86. doi: 10.1158/0008-5472.CAN-11-1094. Epub 2011 Aug 2.
9
Hypoxia in cancer: significance and impact on clinical outcome.癌症中的缺氧：意义及其对临床结局的影响。
Cancer Metastasis Rev. 2007 Jun;26(2):225-39. doi: 10.1007/s10555-007-9055-1.
10
The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.皮肤的缺氧微环境有助于Akt介导的黑素细胞转化。
Cancer Cell. 2005 Dec;8(6):443-54. doi: 10.1016/j.ccr.2005.11.005.