McMahon Meagan, Ye Siying, Pedrina Jess, Dlugolenski Daniel, Stambas John
Faculty of Health, School of Medicine, Deakin University, Geelong, VIC, Australia.
Front Mol Biosci. 2021 Aug 30;8:703868. doi: 10.3389/fmolb.2021.703868. eCollection 2021.
Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases (ADAMs) and ADAMs with Thombospondin-1 motifs (ADAMTS) play a vital role in pathogen defence and have been shown to influence migration of immune cells. This review provides a current summary of the role of ECM enzymes in immune cell migration and function and discusses opportunities and limitations for development of diagnostic and therapeutic strategies targeting metalloproteinase expression and activity in the context of infectious disease.
细胞外基质金属蛋白酶对细胞外基质（ECM）的重塑与免疫细胞功能的调节之间的关联日益紧密。细胞外基质金属蛋白酶，包括基质金属蛋白酶（MMPs）、解聚素和金属蛋白酶（ADAMs）以及含血小板反应蛋白基序的解聚素和金属蛋白酶（ADAMTS），在病原体防御中发挥着至关重要的作用，并且已被证明会影响免疫细胞的迁移。本综述对细胞外基质酶在免疫细胞迁移和功能中的作用进行了当前总结，并讨论了在传染病背景下针对金属蛋白酶表达和活性开发诊断和治疗策略的机遇与局限。
