Hause Ben M, Nelson Eric, Christopher-Hennings Jane
Animal Disease Research and Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, 57007, USA.
Arch Virol. 2021 Nov;166(11):3193-3197. doi: 10.1007/s00705-021-05231-7. Epub 2021 Sep 15.
Bovine enteric disease has a complex etiology that can include viral, bacterial, and parasitic pathogens and is a significant source of losses due to morbidity and mortality. Boosepivirus was identified in calves with enteric disease with unclear etiology in Japan in 2009 and has not been reported elsewhere. Metagenomic sequencing and PCR here identified boosepivirus in bovine enteric disease diagnostic submissions from six states in the USA with 98% sequence identity to members of the species Boosepivirus B. In all cases, boosepivirus was identified as a coinfection with the established pathogens bovine coronavirus, bovine rotavirus, and cryptosporidia. Further research is needed to determine the clinical significance of boosepivirus infection.
牛肠道疾病病因复杂，可能包括病毒、细菌和寄生虫病原体，是发病率和死亡率导致损失的重要来源。2009年在日本病因不明的患肠道疾病犊牛中发现了布氏瘟病毒，其他地方尚未见报道。本文通过宏基因组测序和聚合酶链反应在美国六个州的牛肠道疾病诊断样本中鉴定出布氏瘟病毒，其与布氏瘟病毒B种成员的序列同一性为98%。在所有病例中，布氏瘟病毒被鉴定为与已确定的病原体牛冠状病毒、牛轮状病毒和隐孢子虫共同感染。需要进一步研究以确定布氏瘟病毒感染的临床意义。
