瞬时受体电位香草酸亚型1：皮肤衰老和炎症性皮肤病一个有前景的治疗靶点。
TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases.
作者信息
Xiao Tengfei, Sun Mingzhong, Zhao Chuanxiang, Kang Jingjing
机构信息
Department of Clinical Laboratory, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, Jiangsu, China.
Institute of Medical Genetics and Reproductive Immunity, School of Medical Science and Laboratory Medicine, Jiangsu College of Nursing, Huai'an, Jiangsu, China.
出版信息
Front Pharmacol. 2023 Feb 15;14:1037925. doi: 10.3389/fphar.2023.1037925. eCollection 2023.
TRPV1 is a non-selective channel receptor widely expressed in skin tissues, including keratinocytes, peripheral sensory nerve fibers and immune cells. It is activated by a variety of exogenous or endogenous inflammatory mediators, triggering neuropeptide release and neurogenic inflammatory response. Previous studies have shown that TRPV1 is closely related to the occurrence and/or development of skin aging and various chronic inflammatory skin diseases, such as psoriasis, atopic dermatitis, rosacea, herpes zoster, allergic contact dermatitis and prurigo nodularis. This review summarizes the structure of the TRPV1 channel and discusses the expression of TRPV1 in the skin as well as its role of TRPV1 in skin aging and inflammatory skin diseases.
瞬时受体电位香草酸亚型1（TRPV1）是一种非选择性通道受体，广泛表达于皮肤组织中，包括角质形成细胞、外周感觉神经纤维和免疫细胞。它可被多种外源性或内源性炎症介质激活，引发神经肽释放和神经源性炎症反应。先前的研究表明，TRPV1与皮肤衰老以及各种慢性炎症性皮肤病（如银屑病、特应性皮炎、酒渣鼻、带状疱疹、过敏性接触性皮炎和结节性痒疹）的发生和/或发展密切相关。本文综述了TRPV1通道的结构，讨论了TRPV1在皮肤中的表达及其在皮肤衰老和炎症性皮肤病中的作用。
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