School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China.
Chem Commun (Camb). 2021 Sep 16;57(74):9316-9329. doi: 10.1039/d1cc04029d.
Although transition metal carbenes have found widespread applications and difluorocarbene has served as a versatile intermediate, it is still quite challenging to make use of transition-metal difluorocarbenes in synthetic chemistry due to their unpredictable reactivities. In this Highlight, we review recent developments in the transition-metal-catalyzed or -mediated transfer of difluorocarbene and the reactivies and conversions of transition-metal difluorocarbene complexes. We start with the MCF bonding, then provide the progress in the transfer of difluorocarbene, and finally briefly discuss the conversions of MCF into other metal complexes. The understanding of the interesting reactivities of MCF may help design the catalytic transfer of difluorocarbene for various reactions.
尽管过渡金属卡宾得到了广泛的应用，二氟卡宾也作为一种多功能的中间体，但由于其不可预测的反应性，在合成化学中利用过渡金属二氟卡宾仍然具有相当大的挑战性。在这篇综述中，我们回顾了近年来过渡金属催化或介导的二氟卡宾转移以及过渡金属二氟卡宾配合物的反应性和转化方面的进展。我们从 M-CF 键开始，然后提供二氟卡宾转移的进展，最后简要讨论 M-CF 转化为其他金属配合物的情况。对 M-CF 有趣反应性的理解可能有助于设计用于各种反应的二氟卡宾催化转移。
