早产和低体重新生儿的急性肾损伤：一项系统评价和荟萃分析。
Acute kidney injury in premature and low birth weight neonates: a systematic review and meta-analysis.
作者信息
Wu Yang, Wang Haoran, Pei Jiao, Jiang Xiaoping, Tang Jun
机构信息
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, Sichuan University, Chengdu, China.
出版信息
Pediatr Nephrol. 2022 Feb;37(2):275-287. doi: 10.1007/s00467-021-05251-0. Epub 2021 Sep 16.
BACKGROUND
Acute kidney injury (AKI) is common and it is associated with poor clinical outcomes in premature and low birth weight neonates. This systematic review and meta-analysis was performed to summarize the literature and evaluate the prevalence, risk factors, and mortality of premature and low birth weight neonates with AKI.
METHODS
A systematic search in PubMed, Embase, and the Cochrane Library was performed. Studies on the prevalence, risk factors, diagnosis, and outcomes of acute kidney injury in preterm neonates and neonates with low birth weight were included and analyzed.
RESULTS
Fifty articles of 10,744 patients were included in this study. The overall rate of AKI from the pooled results of all patients was 25% (95% CI 20-30%) with heterogeneity among studies (I = 97%; P < 0.01). Patients with AKI had significantly higher rate of mortality than patients without AKI (odds ratio (OR) = 7.13; 95% CI 5.91-8.60; P < 0.01).
CONCLUSIONS
AKI was prevalent and was associated with high mortality rate among preterm and low birth weight neonates.
背景
急性肾损伤（AKI）很常见，并且与早产和低出生体重新生儿的不良临床结局相关。进行这项系统评价和荟萃分析以总结文献，并评估早产和低出生体重AKI新生儿的患病率、危险因素及死亡率。
方法
在PubMed、Embase和Cochrane图书馆进行系统检索。纳入并分析关于早产儿和低出生体重儿急性肾损伤的患病率、危险因素、诊断及结局的研究。
结果
本研究纳入了10744例患者的50篇文章。所有患者汇总结果的AKI总体发生率为25%（95%CI 20 - 30%），各研究间存在异质性（I = 97%；P < 0.01）。AKI患者的死亡率显著高于无AKI患者（优势比（OR）= 7.13；95%CI 5.91 - 8.60；P < 0.01）。
结论
AKI在早产和低出生体重新生儿中很普遍，且与高死亡率相关。
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