评论“异常的 1 型免疫驱动黏膜真菌感染易感性”。
Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
机构信息
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
University of Paris, Imagine Institute, Paris, France.
出版信息
Science. 2021 Sep 17;373(6561):eabi5459. doi: 10.1126/science.abi5459. Epub 2021 Sep 16.
Abstract
Break . (Research Articles, 15 January 2021, eaay5731) suggest that chronic mucocutaneous candidiasis in humans with inborn errors of and autoimmune polyendocrine syndrome type 1 is due to excessive interferon-γ production and not to autoantibodies neutralizing interleukin-17 cytokines. We argue that both claims are not conclusively supported by their data and are at odds with 35 years of study.
摘要
（研究文章，2021 年 1 月 15 日，eaay5731）表明，先天性免疫缺陷和 1 型自身免疫性多内分泌综合征患者的慢性黏膜皮肤念珠菌病是由于干扰素-γ产生过多，而不是中和白细胞介素-17 细胞因子的自身抗体所致。我们认为，他们的数据并没有确凿地支持这两种说法，而且与 35 年的研究结果相悖。
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