评论“异常的 1 型免疫驱动黏膜真菌感染易感性”。
Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
机构信息
Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Regaem Consultants, Whitchurch Gardens, Edgware, Middlesex, UK.
出版信息
Science. 2021 Sep 17;373(6561):eabi6235. doi: 10.1126/science.abi6235. Epub 2021 Sep 16.
Break . (Research Articles, 15 January 2021, eaay5731) conclude that T cell overproduction of interferon-γ causes chronic mucocutaneous candidiasis (CMC), a typical early feature of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED). This contradicts studies implicating interleukin IL-17 and IL-22 deficiencies as a cause of CMC. We propose that Break . have focused on late-arising events rather than more common primary causes of CMC.
研究论文指出，T 细胞过度产生干扰素-γ会导致慢性黏膜皮肤念珠菌病（CMC），这是自身免疫性多内分泌腺病-念珠菌病-外胚层营养不良（APECED）的一个典型早期特征。这与暗示白细胞介素 IL-17 和 IL-22 缺乏是 CMC 病因的研究结果相矛盾。我们提出，Break. 专注于后期出现的事件，而不是 CMC 更常见的主要原因。
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