Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Regaem Consultants, Whitchurch Gardens, Edgware, Middlesex, UK.
Science. 2021 Sep 17;373(6561):eabi6235. doi: 10.1126/science.abi6235. Epub 2021 Sep 16.
Break . (Research Articles, 15 January 2021, eaay5731) conclude that T cell overproduction of interferon-γ causes chronic mucocutaneous candidiasis (CMC), a typical early feature of autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED). This contradicts studies implicating interleukin IL-17 and IL-22 deficiencies as a cause of CMC. We propose that Break . have focused on late-arising events rather than more common primary causes of CMC.
研究论文指出，T 细胞过度产生干扰素-γ会导致慢性黏膜皮肤念珠菌病（CMC），这是自身免疫性多内分泌腺病-念珠菌病-外胚层营养不良（APECED）的一个典型早期特征。这与暗示白细胞介素 IL-17 和 IL-22 缺乏是 CMC 病因的研究结果相矛盾。我们提出，Break. 专注于后期出现的事件，而不是 CMC 更常见的主要原因。
