Tarnecki R, Morrison A R, Rajkowski J, Sarna M F, Zurawska I
Laboratory of Afferent Systems, Nencki Institute of Experimental Biology, Warsaw.
Acta Physiol Pol. 1987 Jul-Aug;38(4):302-22.
Spontaneous and evoked activities of nucleus interpositus neurons (IN) of the cerebellum were examined before and after cerebellar paravermal cortex lesions in cats anesthetized with alpha-chloralose. It was found that spontaneous activity increased dramatically following cortical ablation: before the lesion only 4% of cells encountered fired at a rate exceeding 80 impulses/sec., whereas up to 40% discharged at this rate postoperatively. Responses to paw stimulation were also altered: the initial excitation was lengthened from 8.5 to 15.8 msec; narrow; trough causing segmentation in this excitation, which seems to result from Purkinje cell inhibition, was absent; and the succeeding inhibitory period was reduced in duration by 50%. Also after the lesion there was a strong tendency for the neurons to discharge in bursts. It is suggested that changes in cell activity in the IN following cortical lesion unveil neural mechanisms of motor disturbances in lesioned cats.
在用α-氯醛糖麻醉的猫中，研究了小脑旁中央小叶皮质损伤前后小脑间位核神经元（IN）的自发活动和诱发活动。结果发现，皮质切除后自发活动显著增加：损伤前仅4%的所记录细胞放电频率超过80次/秒，而术后高达40%的细胞以该频率放电。对爪部刺激的反应也发生了改变：初始兴奋期从8.5毫秒延长至15.8毫秒；狭窄的、由浦肯野细胞抑制导致该兴奋期出现分段的波谷消失；随后的抑制期持续时间缩短了50%。损伤后神经元还有强烈的成簇放电倾向。提示皮质损伤后IN中细胞活动的变化揭示了损伤猫运动障碍的神经机制。
