Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Acta Oncol. 2021 Dec;60(12):1572-1579. doi: 10.1080/0284186X.2021.1973679. Epub 2021 Sep 16.
The results of studies on the relationship between cancer and COVID-19 have been conflicting and therefore further studies are needed. We aimed to examine the incidence of COVID-19 among patients at one of the largest oncology departments in Sweden, and to evaluate and identify risk factors for poor outcomes, hospital care and death, associated with COVID-19 among cancer patients.
This retrospective study included cancer patients at a single center who tested positive for SARS-CoV-2 by PCR either in hospital, primary health care center or commercial laboratory between 1 March and 14 August 2020. Clinical and demographic data were collected from the medical records. Logistic regression analysis was used to identify variables that associated the primary outcomes of need for hospital care and death within 30 days of positive test.
Of 10,774 patients from the Department of Oncology at Sahlgrenska University Hospital, 135 tested positive for SARS-CoV-2 (1.3%). Twenty-eight patients were excluded from further the data collection since they did not meet the inclusion criteria. Altogether, 107 cancer patients were included and the case fatality rate (CFR) was 12% (13) within 30 days of confirmed SARS-CoV-2 infection by PCR. Increasing years of age (OR 1.10; CI 95% 1.03-1.18), palliative treatment intent (OR 15.7; CI 95% 1.8-135.8), and transition to end-of-life care (OR 52.0; CI 95% 3.7-735.6) were associated with increased odds of death within 30 days. Male sex was associated with needing hospital care (OR 3.7; CI 95% 1.50-9.1).
As in the general population, male sex was found to be at greater risk of needing hospital care for COVID-19, with terminal cancer disease, and older age increasing the odds of fatality. Compared to the general population, slightly more cancer patients had COVID-19. The CFR was within the lower range of others reported in cancer patients.
关于癌症与 COVID-19 之间关系的研究结果存在矛盾，因此需要进一步研究。我们旨在研究瑞典最大的肿瘤学部门之一的患者中 COVID-19 的发病率，并评估和确定与癌症患者 COVID-19 相关的不良结局、住院治疗和死亡的风险因素。
这项回顾性研究包括 2020 年 3 月 1 日至 8 月 14 日期间，在医院、初级保健中心或商业实验室通过 PCR 检测 SARS-CoV-2 呈阳性的单一中心的癌症患者。从病历中收集临床和人口统计学数据。使用逻辑回归分析来确定与 30 天内阳性检测后需要住院治疗和死亡相关的主要结局的变量。
在萨赫林斯卡大学医院肿瘤科的 10774 名患者中，有 135 名患者 SARS-CoV-2 检测呈阳性（1.3%）。由于不符合纳入标准，有 28 名患者被排除在进一步的数据收集之外。总共纳入了 107 名癌症患者，PCR 确认 SARS-CoV-2 感染后 30 天内的病死率（CFR）为 12%（13）。年龄增长（OR 1.10；95%CI 1.03-1.18）、姑息治疗意向（OR 15.7；95%CI 1.8-135.8）和过渡到终末期护理（OR 52.0；95%CI 3.7-735.6）与 30 天内死亡的可能性增加相关。男性（OR 3.7；95%CI 1.50-9.1）与需要住院治疗 COVID-19 相关。
与一般人群一样，男性在因 COVID-19 住院治疗方面的风险更高，患有晚期癌症疾病和年龄较大的患者死亡的可能性更高。与一般人群相比，癌症患者 COVID-19 的发病率略高。CFR 处于癌症患者报告的较低范围内。
