UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.
Unidad de Gestión Clínica (UCG) de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.
Int J Clin Pract. 2021 Apr;75(4):e13707. doi: 10.1111/ijcp.13707. Epub 2020 Dec 14.
To describe the incidence and fatality of coronavirus disease 2019 (COVID-19) and identify risk factors to fatality in patients with inflammatory articular diseases (IAD).
This is a cross-sectional observational study of IAD patients and COVID-19 with controls matched for age, sex, and RT-PCR. A control group was used to compare the cumulative incidence (CI) and case fatality rate (CFR). The main outcomes of the study were CI and CFR. Other variables included comorbidities, treatments, and characteristics of the COVID-19. Multiple logistic regression analysis was performed to investigate risk factors for fatality in patients with IAD.
Of the 1537 patients who fulfilled the inclusion criteria, 23/1537 (1.49%) had IAD 13 (0.8%) had rheumatoid arthritis (RA), 5 psoriatic arthritis (PsA) (0.3%) and 5 axial spondyloarthritis (0.3%). There were no significant differences in CI of COVID-19 and CFR in patients with IAD compared with COVID-19 patients without IAD. In RT-PCR positive patients, the CI of COVID-19 in PsA and AS was higher. Of the 23 IAD patients, 2 RA patients (8.6%) died. The patients did no show characteristics of the COVID-19 disease different from the population. In multivariate analysis, the factor associated with fatality in patients with IAD was older age (OR [95% CI], 1.1 [1.0-1.2]).
COVID-19 CI, fatality rate and other features do not seem to be increased in IAD patients. Older age was associated with fatality in patients with IAD.
描述 2019 年冠状病毒病（COVID-19）的发病率和病死率，并确定炎症性关节病（IAD）患者死亡的危险因素。
这是一项针对 IAD 患者和 COVID-19 的横断面观察性研究，对照者按年龄、性别和 RT-PCR 匹配。使用对照组比较累积发病率（CI）和病死率（CFR）。本研究的主要结局是 CI 和 CFR。其他变量包括合并症、治疗和 COVID-19 的特征。采用多因素 logistic 回归分析探讨 IAD 患者死亡的危险因素。
在符合纳入标准的 1537 例患者中，23/1537（1.49%）患有 IAD，13/1537（0.8%）患有类风湿关节炎（RA），5 例患有银屑病关节炎（PsA）（0.3%）和 5 例患有中轴型脊柱关节炎（0.3%）。与无 IAD 的 COVID-19 患者相比，IAD 患者的 COVID-19 CI 和 CFR 无显著差异。在 RT-PCR 阳性患者中，PsA 和 AS 的 COVID-19 CI 较高。在 23 例 IAD 患者中，2 例 RA 患者（8.6%）死亡。这些患者的 COVID-19 疾病特征与人群无差异。多因素分析显示，IAD 患者死亡的相关因素是年龄较大（OR[95%CI]，1.1[1.0-1.2]）。
COVID-19 的 CI、病死率和其他特征似乎并未在 IAD 患者中增加。年龄较大与 IAD 患者的死亡相关。
