University of Eastern Finland, Kuopio, Finland.
University of Turku, Turku, Finland.
BMC Cardiovasc Disord. 2021 Sep 16;21(1):444. doi: 10.1186/s12872-021-02252-7.
Effective prevention and treatment of hypertension is one of the most potential interventions in terms of preventing cardiovascular deaths and disabilities. However, the treatment control is often poor. This may be partly explained by the impact of hypertension diagnoses and treatment on health-related quality of life. Quality of life is also an important outcome for a hypertensive patient. Most of the previous studies on health-related quality of life in hypertension have concentrated on patients with treated hypertension and less is known about the initiation of medication and the first treatment year.
In this interventional study, we followed 111 primary care patients with newly diagnosed hypertension in real world primary care setting in Finland for 12 months.
We found significant decrease in both systolic and diastolic blood pressure levels, as well as modest decrease in cholesterol levels and alcohol consumption. However, the health-related quality of life also slightly deteriorated during the first treatment year.
Our study shows that the initiation of hypertension treatment results in cardiovascular risk decrease among newly diagnosed Finnish hypertensive patients, but it is accompanied by small negative impact on health-related quality of life. However, the deterioration in health-related quality of life is of small magnitude and earlier research demonstrates several measures to enhance treatment and avoid impairment in health-related quality of life. Trial registration ClinicalTrials NCT02377960 (Date of registration: 04/03/2015).
有效预防和治疗高血压是预防心血管疾病死亡和残疾的最有潜力的干预措施之一。然而，治疗控制往往很差。这可能部分解释了高血压诊断和治疗对健康相关生活质量的影响。生活质量也是高血压患者的一个重要结果。以前关于高血压患者健康相关生活质量的大多数研究都集中在接受治疗的高血压患者上，而对药物治疗的开始和第一年治疗知之甚少。
在这项干预性研究中，我们在芬兰的真实初级保健环境中对 111 名新诊断的高血压初级保健患者进行了为期 12 个月的随访。
我们发现收缩压和舒张压水平均显著下降，胆固醇水平和饮酒量也适度下降。然而，在第一年的治疗中，健康相关的生活质量也略有恶化。
我们的研究表明，高血压治疗的开始会降低新诊断的芬兰高血压患者的心血管风险，但同时也对健康相关的生活质量产生微小的负面影响。然而，健康相关生活质量的恶化程度很小，早期研究表明有几种措施可以提高治疗效果，避免健康相关生活质量受损。试验注册 ClinicalTrials NCT02377960（注册日期：2015 年 3 月 4 日）。
