Jneid Siba, Jabbour Hicham, Hajj Aline, Sarkis Antoine, Licha Hady, Hallit Souheil, Khabbaz Lydia Rabbaa
1 Pharmacology, Clinical Pharmacy and Quality Control Laboratory, Faculty of Pharmacy, Saint-Joseph University of Beirut, Beirut, Lebanon.
2 Faculty of Pharmacy, Saint-Joseph University of Beirut, Beirut, Lebanon.
J Cardiovasc Pharmacol Ther. 2018 Nov;23(6):532-542. doi: 10.1177/1074248418784292. Epub 2018 Jun 19.
Patients with hypertension tend to have a lower health-related quality of life (HRQOL) compared to normotensive patients. This study's main objectives are to assess (1) HRQOL and factors that might impact it and (2) association between HRQOL and adherence to treatment, trust in physician, and treatment satisfaction among patients with hypertension.
A cross-sectional study enrolled 196 patients from medical-care offices in Beirut, North and South Lebanon. Eligible patients signed a consent form and were asked to complete the Trust in Physician Scale, World Health Organization Quality of Life-brief (WHOQOL-brief) questionnaire, and Treatment Satisfaction Questionnaire (TSQM 1.4) as well as questions assessing medication adherence.
Better antihypertensive medication adherence was significantly and positively correlated with better HRQOL domains except general health where significance was not reached ( P = .089). Better adherence was also significantly related to better treatment satisfaction (side effects, convenience, and global satisfaction but not to effectiveness) and an increased trust in physicians ( P < .0001). Better treatment satisfaction (TSQM domains) was significantly and positively associated with a better overall HRQOL ( P ≤ .001). Increased trust in physician scores were significantly and positively correlated with a better psychological health, environment, and overall HRQOL domains ( P = .045, .005, and .006, respectively). Finally, TSQM effectiveness, convenience, and global satisfaction were significantly higher when trust in physician was greater ( P = .017, .035, and .002, respectively).
The results of this study revealed an association between increased adherence to treatment, a higher global satisfaction, and an increased quality of life. An increased patient satisfaction with their antihypertensive treatment and trust in their physician were also correlated with a greater adherence to treatment.
与血压正常的患者相比，高血压患者的健康相关生活质量（HRQOL）往往较低。本研究的主要目的是评估：（1）HRQOL及其可能受到影响的因素；（2）高血压患者的HRQOL与治疗依从性、对医生的信任以及治疗满意度之间的关联。
一项横断面研究纳入了来自黎巴嫩北部、南部和贝鲁特医疗诊所的196名患者。符合条件的患者签署了知情同意书，并被要求完成《对医生的信任量表》、世界卫生组织生活质量简表（WHOQOL-简表）问卷、治疗满意度问卷（TSQM 1.4）以及评估药物依从性的问题。
更好的抗高血压药物依从性与除总体健康外的更好的HRQOL领域显著正相关（总体健康领域未达到显著水平，P = 0.089）。更好的依从性还与更好的治疗满意度（副作用、便利性和总体满意度，但与有效性无关）以及对医生的信任增加显著相关（P < 0.0001）。更好的治疗满意度（TSQM领域）与更好的总体HRQOL显著正相关（P≤0.001）。对医生信任得分的增加与更好的心理健康、环境和总体HRQOL领域显著正相关（分别为P = 0.045、0.005和0.006）。最后，当对医生的信任度更高时，TSQM的有效性、便利性和总体满意度显著更高（分别为P = 0.017、0.035和0.002）。
本研究结果揭示了治疗依从性增加、总体满意度提高与生活质量提高之间的关联。患者对其抗高血压治疗的满意度增加以及对医生的信任也与更高的治疗依从性相关。
