Department of Oral and Maxillofacial Surgery and Traumatology, University of Pernambuco - School of Dentistry (UPE/FOP), University Hospital Oswaldo Cruz, Rua Arnóbio Marquês, 310 - Santo Amaro, Recife, PE, CEP: 50.100-130, Brazil.
Br J Oral Maxillofac Surg. 2021 Nov;59(9):993-1004. doi: 10.1016/j.bjoms.2020.12.012. Epub 2021 Sep 14.
The aim of the present study was to perform a systematic review of the need for the latency period in distraction osteogenesis to obtain adequate bone formation. Searches were performed in the Web of Science, Pubmed/MEDLINE, Scopus, and Cochrane electronic databases. Nine articles were selected for qualitative analysis. Quality assessment was performed using the 10-item SYRCLE tool. Clinical stability was evaluated in two articles, histology was analysed in seven, histomorphometry was analysed in three, and mechanical testing was used in two. The results favoured the five-day latency group in two studies and the seven-day latency group in one. No differences were found between latency and no-latency groups in six studies. A latency period greater than seven days did not provide any additional benefit. Important risks of bias were found in all articles. Some of the results were influenced by uncontrolled intervening factors, such as consolidation time. The need for a latency period for distraction osteogenesis in animal models is not yet clear. Caution must be exercised when extrapolating the results of animal protocols to applications with humans in the clinical setting.
本研究旨在对牵张成骨过程中潜伏期的必要性进行系统评价，以获得足够的骨形成。在 Web of Science、Pubmed/MEDLINE、Scopus 和 Cochrane 电子数据库中进行了检索。选择了 9 篇文章进行定性分析。使用 SYRCLE 工具的 10 项指标对质量进行评估。两篇文章评估了临床稳定性，七篇文章分析了组织学，三篇文章分析了组织形态计量学，两篇文章使用了机械测试。两项研究结果支持 5 天潜伏期组，一项研究结果支持 7 天潜伏期组。六篇研究中未发现潜伏期和无潜伏期组之间存在差异。大于 7 天的潜伏期没有提供任何额外的益处。所有文章均发现存在重要的偏倚风险。一些结果受到不可控的干预因素的影响，例如整合时间。动物模型中牵张成骨潜伏期的需求尚不清楚。在将动物方案的结果外推应用于临床环境中的人类时，必须谨慎。
