Dupont C, Antonini M T, Denoyer M, Lemaire F, Menier R, Chassain A P
Services de Pédiatrie, Bouquier C.H.U. Dupuytren, Limoges.
Allerg Immunol (Paris). 1987 Apr;19(4):135-41.
The purpose of pulmonary function testing in children with asthma is to search for obstructive airway disease. We examined the charts of 169 asthmatic children during intervals between acute exacerbations. The severity of asthma was determined according to VIALATTE classification, with the Tiffeneau ration FEV1/VC (1) and the MMFR/VC ratio serving as obstructive indices. According to these data, children were classified into three groups: normal children (normal FEV1/VC and MMFR/VC), children with probable obstruction of the distal airways (normal FEV1/VC and decreased MMFR/VC), and children with both proximal and distal airway obstruction (decreased FEV1/VC and MMFR/VC). Since suggested normal values vary in the literature, we compared FEV1 and MMFR to determine as accurately as possible the number of children with obstructive disease. The relationship between the degree of clinical involvement and pulmonary function testing results was studied. Clinically, asymptomatic children with suspected normal respiratory function had evidence of obstructive disease in two out of three cases, and would benefit from drug therapy.
对哮喘患儿进行肺功能测试的目的是查找阻塞性气道疾病。我们在169例哮喘患儿急性加重期的间歇期检查了他们的病历。根据维亚拉特分类法确定哮喘的严重程度，采用蒂费诺比率FEV1/VC(1)和MMFR/VC比率作为阻塞指标。根据这些数据，将患儿分为三组：正常儿童（FEV1/VC和MMFR/VC正常）、可能存在远端气道阻塞的儿童（FEV1/VC正常但MMFR/VC降低）以及近端和远端气道均有阻塞的儿童（FEV1/VC和MMFR/VC均降低）。由于文献中建议的正常值各不相同，我们比较了FEV1和MMFR，以尽可能准确地确定患有阻塞性疾病的儿童数量。研究了临床受累程度与肺功能测试结果之间的关系。临床上，疑似呼吸功能正常的无症状儿童中有三分之二存在阻塞性疾病的证据，且将从药物治疗中获益。
