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肿瘤心脏病学的现状与未来展望:早期发现和干预心脏毒性以及新型癌症治疗心血管并发症的重要性。

Current status and future perspectives of onco-cardiology: Importance of early detection and intervention for cardiotoxicity, and cardiovascular complication of novel cancer treatment.

作者信息

Kubota Shuji, Hara Hisao, Hiroi Yukio

机构信息

Department of Cardiology, National Center for Global Health and Medicine, Tokyo, Japan.

出版信息

Glob Health Med. 2021 Aug 31;3(4):214-225. doi: 10.35772/ghm.2021.01024.

Abstract

The prognosis has improved remarkably in recent years with the development of cancer treatment. With the increase in the number of cancer survivors, complications of cardiovascular disease have become a problem. Therefore, the field of onco-cardiology has been attracting attention. The field of onco-cardiology covers a wide range of areas. In the past, cardiac dysfunction caused by cardiotoxic drug therapies such as doxorubicin (Adriamycin) was the most common cause of cardiac dysfunction, but nowadays, cardiovascular complications caused by aging cancer survivors, atherosclerotic disease in cardiovascular risk carriers, thromboembolism, and new drugs (, myocarditis caused by immune checkpoint inhibitors and hypertension caused by angiogenesis) are becoming more common. In this review, we summarize the latest findings of cardiotoxicity of cancer therapy, appropriate treatment and prevention, and cardiovascular complications of novel chemotherapy, which will increase in demand in the near future.

摘要

近年来,随着癌症治疗的发展,预后有了显著改善。随着癌症幸存者数量的增加,心血管疾病并发症已成为一个问题。因此,肿瘤心脏病学领域受到了关注。肿瘤心脏病学领域涵盖广泛。过去,由多柔比星(阿霉素)等心脏毒性药物治疗引起的心脏功能障碍是心脏功能障碍最常见的原因,但如今,老年癌症幸存者引起的心血管并发症、心血管风险携带者的动脉粥样硬化疾病、血栓栓塞以及新药(免疫检查点抑制剂引起的心肌炎和血管生成引起的高血压)正变得越来越普遍。在这篇综述中,我们总结了癌症治疗心脏毒性的最新发现、适当的治疗和预防,以及新型化疗的心血管并发症,这些在不久的将来需求将会增加。

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