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2021 年 6 月至 7 月，法国社区中 SARS-CoV-2 Delta 和 Alpha 变异株疫苗突破性感染的特征及病毒载量动力学。

Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021.

机构信息

Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France.

LBM BIOESTEREL-Biogroup-Plateau technique de Mouans-Sartoux, Mouans-Sartoux, France.

出版信息

Euro Surveill. 2021 Sep;26(37). doi: 10.2807/1560-7917.ES.2021.26.37.2100824.

DOI:10.2807/1560-7917.ES.2021.26.37.2100824
PMID:34533119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8447828/
Abstract

We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1-2.3; p < 10-6). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: -3.32; 95% CI: -4.38 to -2.25; p < 10-6).

摘要

我们比较了 2021 年 6 月 14 日至 7 月 30 日期间在法国社区接受检测的 SARS-CoV-2 阳性患者的 PCR 结果。在无症状个体中，完全接种疫苗者的 Cq 值明显高于未完全接种疫苗者（效应量：1.7；95%CI：1-2.3；p<10-6）。在有症状个体中并控制症状出现后的时间，这种差异消失（p=0.26）。与 Alpha 变体相比，Delta 变体感染在出现症状时的 Cq 值更低（效应量：-3.32；95%CI：-4.38 至-2.25；p<10-6）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9d6/8447828/ec182ec91b8d/2100824-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9d6/8447828/0671620b14e0/2100824-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9d6/8447828/ec182ec91b8d/2100824-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9d6/8447828/0671620b14e0/2100824-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9d6/8447828/ec182ec91b8d/2100824-f2.jpg

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1
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2
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Clin Microbiol Infect. 2022 Apr;28(4):612.e1-612.e7. doi: 10.1016/j.cmi.2021.11.010. Epub 2021 Nov 23.
3
Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant.
Association of Demographic, Clinical, and Vaccination Characteristics with COVID-19 Viral Load Assessed by qRT-PCR.
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4
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Access Microbiol. 2023 Oct 20;5(10). doi: 10.1099/acmi.0.000597.v3. eCollection 2023.
5
Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates.关注变异株对非人类灵长类动物中 SARS-CoV-2 病毒动力学的影响。
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6
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7
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8
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9
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Epidemiological and clinical characteristics of vaccinated COVID-19 patients: A meta-analysis and systematic review.接种 COVID-19 疫苗患者的流行病学和临床特征：荟萃分析和系统评价。
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4
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5
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Nature. 2021 Nov;599(7883):114-119. doi: 10.1038/s41586-021-03944-y. Epub 2021 Sep 6.
6
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Clin Infect Dis. 2022 Aug 24;75(1):e1128-e1136. doi: 10.1093/cid/ciab721.
7
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