并比较了三种具有不同外壳的紫云英宁包封玉米醇溶蛋白纳米粒。
and comparison of three astilbin encapsulated zein nanoparticles with different outer shells.
机构信息
Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.
出版信息
Food Funct. 2021 Oct 19;12(20):9784-9792. doi: 10.1039/d1fo01522b.
Three shell materials, lecithin (ZNP-L), chitosan (ZNP-CH) and sodium caseinate (ZNP-SC), were used to prepare core-shell zein nanoparticles. Astilbin was encapsulated as a model flavonoid to compare the influence of the shell materials on zein nanoparticles both and . The particle size was moderately increased by lecithin and sodium caseinate, but notably increased by chitosan. All the shell materials provided good redispersibility for the nanoparticles and significantly improved the colloidal stability. Chitosan and sodium caseinate significantly delayed and decreased the feces excretion of astilbin in rats, while lecithin exhibited a very weak effect. The results may be attributed to the difference in mucoadhesive properties between the shell materials. As a consequence, the bioavailability values of astilbin in rats were 18.2, 9.3 and 1.89 times increased through ZNP-CH, ZNP-SC and ZNP-L compared with that of free astilbin, respectively.
三种壳材料，即卵磷脂（ZNP-L）、壳聚糖（ZNP-CH）和酪蛋白酸钠（ZNP-SC），被用于制备核壳结构的玉米醇溶蛋白纳米粒。采用紫云英苷作为模型黄酮类化合物，比较了壳材料对玉米醇溶蛋白纳米粒的影响。卵磷脂和酪蛋白酸钠适度增加了颗粒粒径，而壳聚糖则显著增加了粒径。所有壳材料均为纳米粒提供了良好的再分散性，并显著提高了胶体稳定性。壳聚糖和酪蛋白酸钠显著延缓并减少了紫云英苷在大鼠粪便中的排泄，而卵磷脂则表现出非常微弱的效果。结果可能归因于壳材料之间的粘膜粘附性能的差异。因此，与游离紫云英苷相比，大鼠中紫云英苷的生物利用度值分别通过 ZNP-CH、ZNP-SC 和 ZNP-L 提高了 18.2、9.3 和 1.89 倍。
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