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基于免疫调节植物的碳点用于癌细胞成像、自由基清除和金属传感应用。

Carbon dots from an immunomodulatory plant for cancer cell imaging, free radical scavenging and metal sensing applications.

机构信息

Phytomedicine Research Lab, Department of Pharmaceutical Engineering & Technology, IIT (BHU), Varanasi, Uttar Pradesh, 221005, India.

Department of Physics, IIT (BHU), Varanasi, Uttar Pradesh, 221005, India.

出版信息

Nanomedicine (Lond). 2021 Oct;16(23):2039-2059. doi: 10.2217/nnm-2021-0190. Epub 2021 Sep 17.

Abstract

This work aimed to develop stem-derived carbon dots (TCSCD) for cancer cell imaging, free radical scavenging and metal sensing applications. The TCSCDs were synthesized by a simple, one-step, and ecofriendly hydrothermal carbonization method and characterized for their optical properties, morphology, hydrodynamic size, surface functionality, crystallinity, stability, bacterial biocompatibility, cellular imaging, free radical scavenging and metal sensing ability. The TCSCDs exhibited excellent biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. They exerted good free radical scavenging, Fe sensing, bacterial biocompatibility, photostability, colloidal dispersion stability and thermal stability. The results reflect the potential of TCSCDs for biomedical and pharmaceutical applications.

摘要

本工作旨在开发基于干细胞的碳点(TCSCD),用于癌细胞成像、自由基清除和金属传感应用。TCSCD 采用简单、一步法、环保的水热碳化法合成,并对其光学性质、形态、水动力尺寸、表面功能、结晶度、稳定性、细菌相容性、细胞成像、自由基清除和金属传感能力进行了表征。TCSCD 具有优异的生物相容性,在黑色素瘤(B16F10)和宫颈癌(SiHa)细胞系中表现出剂量依赖性的生物成像结果。它们具有良好的自由基清除、Fe 传感、细菌相容性、光稳定性、胶体分散稳定性和热稳定性。研究结果反映了 TCSCD 在生物医学和制药应用方面的潜力。

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