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沙浴辅助柑橘皮制备用于自由基清除和细胞成像的碳点

Sand bath assisted green synthesis of carbon dots from citrus fruit peels for free radical scavenging and cell imaging.

机构信息

Department of Chemistry, School of Science, GITAM (Deemed to be University), Rudraram, Telangana 502329, India; Department of Engineering Chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam 530003, India.

Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, 502285, India.

出版信息

Colloids Surf B Biointerfaces. 2021 Jan;197:111362. doi: 10.1016/j.colsurfb.2020.111362. Epub 2020 Sep 21.

Abstract

A sand bath assisted strategy for the synthesis of fluorescent carbon dots (CDs) using citrus fruit peels as a renewable green resource is reported in this work. The CDs were synthesized without any alkaline or acidic environment. The synthesized CDs were characterized by various spectroscopic and microscopy techniques. The CDs exhibited excellent water solubility and superior optical properties like excitation dependent emission, and multicolor fluorescence. In addition, the CDs have exhibited remarkable free radical scavenging activity (EC: 4.7382 μg ml).The CDs were highly biocompatible and showed lower toxicity. The CDs when modified with folic acid have shown a significant potential as biological labels for cellular imaging at multiple excitations. Synthesis of CDs from natural fruit peels as an excellent carbon source for versatile applications has been demonstrated.

摘要

本文报道了一种利用柑橘果皮作为可再生绿色资源,通过沙浴辅助策略合成荧光碳点(CDs)的方法。该方法在合成过程中无需碱性或酸性环境。通过各种光谱和显微镜技术对合成的 CDs 进行了表征。合成的 CDs 具有良好的水溶性和优越的光学性质,如激发依赖发射和多色荧光。此外,CDs 还表现出显著的自由基清除活性(EC:4.7382 μg ml)。CDs 具有良好的生物相容性,毒性较低。经叶酸修饰的 CDs 具有作为细胞成像的生物标记物的显著潜力,可在多种激发下使用。本研究证明了从天然果皮中合成 CDs 作为多功能应用的优秀碳源的可行性。

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