Cytogenetics and Molecular Biology Lab., Department of Zoology, University of Kalyani, Kalyani, Nadia, 741235, India.
Global Institute of Pharmaceutical Education and Research (Affiliated to Uttarakhand Technical University), Kashipur-244713, India.
Comb Chem High Throughput Screen. 2022;25(14):2341-2357. doi: 10.2174/1386207325666210917111847.
Cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes catalyze the production of pain mediators like Prostaglandins (PGs) and Leukotrienes (LTs), respectively from arachidonic acid.
The COX and LOX enzyme modulators are responsible for the major PGs and LTs mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer's disease, neuropathy and Cardiovascular Syndromes (CVS). Many synthetic Nonsteroidal Anti- Inflammatory Drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting, hyperacidity, gastrointestinal ulcers, CVS, etc. Methods: The natural inhibitors of pain mediators have great acceptance worldwide due to fewer side effects on long-term uses. The present review is an extensive study of the advantages of plantbased vs synthetic inhibitors.
These natural COX and LOX inhibitors control inflammatory response without causing side-effect-related complicacy.
Therefore, the natural COX and LOX inhibitors may be used as alternative medicines for the management of pain and inflammation due to their less toxicity and resistivity.
环氧化酶（COX）和脂氧合酶（LOX）酶分别催化花生四烯酸生成致痛介质，如前列腺素（PGs）和白三烯（LTs）。
COX 和 LOX 酶调节剂负责主要的 PGs 和 LTs 介导的并发症，如哮喘、骨关节炎、类风湿性关节炎、癌症、阿尔茨海默病、神经病和心血管综合征（CVS）。用于治疗的许多合成非甾体抗炎药（NSAIDs）有严重的副作用，如恶心、呕吐、胃酸过多、胃肠道溃疡、CVS 等。方法：由于长期使用时副作用较少，基于植物的天然疼痛介质抑制剂在全球范围内得到了广泛的认可。本综述是对植物性与合成性抑制剂优势的广泛研究。
这些天然 COX 和 LOX 抑制剂可控制炎症反应，而不会引起与副作用相关的并发症。
因此，天然 COX 和 LOX 抑制剂由于其毒性和耐药性较低，可能被用作治疗疼痛和炎症的替代药物。
